Cochrane · systematic review · CD012033
Perioperative intravenous ketamine for acute postoperative pain in adults
Brinck, ECV, Tiippana, E, Heesen, M, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
Pain, Palliative and Supportive CareAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 16.7%Low 0 · 0%Moderate 2 · 33.3%High 3 · 50%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Perioperative intravenous ketamine compared to placebo for acute postoperative pain in adults
Population: adults undergoing any type of surgery
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Opioid consumption(mg morphine equivalents) Perioperative intravenous ketamine vs placebo | no estimate extracted | 65 studies · 4004 participants | Moderate Downgraded: publication bias |
Pain intensity(0‐100 mm VAS. 7 Perioperative intravenous ketamine vs placebo | no estimate extracted | 82 studies · 5004 participants | High |
Time to first request for analgesia/trigger of PCA(minutes) Perioperative intravenous ketamine vs placebo | no estimate extracted | 31 studies · 1678 participants | Moderate Downgraded: publication bias |
Hyperalgesia(cm2) Perioperative intravenous ketamine vs placebo | no estimate extracted | 7 studies · 333 participants | Very low |
CNS adverse events Perioperative intravenous ketamine vs placebo | no estimate extracted | 105 studies · 6538 participants | High |
Postoperative nausea and vomiting Perioperative intravenous ketamine vs placebo | no estimate extracted | 95 studies · 5965 participants | High |