Memantine vs placebo: Efficacy: number of participants who respond to treatment ‐ at 3 months
It is very uncertain whether memantine changes efficacy: number of participants who respond to treatment ‐ at 1 week compared with placebo (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Memantine vs placebo Efficacy: number of participants who respond to treatment ‐ at 1 week · adults (aged 18 years+) with depression in bipolar disorder It is very uncertain whether memantine changes efficacy: number of participants who respond to treatment ‐ at 1 week compared with placebo (very low certainty). Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder (2021) · Cochrane Headline outcomes only | OR 1.08 [0.06, 19.05] | 1 study · 29 participants | Very low |
Memantine vs placebo Efficacy: number of participants who respond to treatment ‐ at 2 weeks · adults (aged 18 years+) with depression in bipolar disorder It is very uncertain whether memantine changes efficacy: number of participants who respond to treatment ‐ at 2 weeks compared with placebo (very low certainty). Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder (2021) · Cochrane Headline outcomes only | OR 4.88 [0.78, 30.29] | 1 study · 29 participants | Very low |
Memantine vs placebo Efficacy: number of participants who respond to treatment ‐ at 4 weeks · adults (aged 18 years+) with depression in bipolar disorder It is very uncertain whether memantine changes efficacy: number of participants who respond to treatment ‐ at 4 weeks compared with placebo (very low certainty). Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder (2021) · Cochrane Headline outcomes only | OR 5.33 [1.02, 27.76] | 1 study · 29 participants | Very low |
Memantine vs placebo Efficacy: number of participants who respond to treatment ‐ at 3 months · adults (aged 18 years+) with depression in bipolar disorder Memantine showed no clear difference in efficacy: number of participants who respond to treatment ‐ at 3… compared with placebo (low certainty). Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder (2021) · Cochrane Headline outcomes only | OR 1.66 [0.69, 4.03] | 2 studies · 261 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.