Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

35 questions · 36 findings · 5 reviews · Neonatal

No studies found 0 · 0%GRADE not reported 4 · 11.1%Very low 7 · 19.4%Low 7 · 19.4%Moderate 18 · 50%High 0 · 0%

Inhaled steroids vs systemic steroids

General conceptual ability (GCA) score at 7 years The test has a standardisation mean of 100 and SD of 15 · Neonates with developing BPD

Inhaled steroids showed no clear difference in general conceptual ability (GCA) score at 7 years The test has a… compared with systemic steroids (moderate certainty).

1 finding from 1 review

Inhaled steroids vs systemic steroids

Systolic blood pressure > 95th percentile at 7 years · Neonates with developing BPD

Inhaled steroids showed no clear difference in systolic blood pressure > 95th percentile at 7 years compared with systemic steroids (moderate certainty).

1 finding from 1 review

Early inhaled steroids (< 2 weeks) vs placebo (among survivors)

CLD at 36 weeks' PMA · very low birth weight preterm neonates

Early inhaled steroid (< 2 weeks) probably leads to lower CLD at 36 weeks' PMA compared with placebo (among survivors) (moderate certainty).

1 finding from 1 review

Early inhaled steroids (< 2 weeks) vs placebo (among all randomised)

Oxygen requirement at 36 weeks' postmenstrual age · very low birth weight preterm neonates

Early inhaled steroids (< 2 weeks) showed no clear difference in CLD at 36 weeks' PMA oxygen dependency at 36 weeks' PMA compared with placebo (among all randomised) (moderate certainty).

1 finding from 1 review

Early inhaled steroids (< 2 weeks) vs placebo (among all randomised)

Death by, or CLD at, 36 weeks' PMA Death or oxygen dependency at 36 weeks' PMA · very low birth weight preterm neonates

Early inhaled steroids (< 2 weeks) probably leads to lower death by, or CLD at, 36 weeks' PMA Death or oxygen dependency at 36… compared with placebo (among all randomised) (moderate certainty).

1 finding from 1 review