Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

61 questions · 63 findings · 10 reviews

No studies found 19 · 30.2%GRADE not reported 8 · 12.7%Very low 15 · 23.8%Low 15 · 23.8%Moderate 6 · 9.5%High 0 · 0%

Herbal mouthwash vs placebo

Plaque · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

Herbal mouthwash reduced some plaque-related indices versus placebo, with low-certainty evidence.

1 finding from 1 review

Herbal mouthwash vs placebo

Cariogenic bacteria (Mutans streptococci) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

Herbal mouthwash reduced Mutans streptococci versus placebo, but certainty is very low.

1 finding from 1 review

Herbal mouthwash vs placebo

Gingival inflammation-related index · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

Herbal mouthwash reduced gingival inflammation-related indices versus placebo, but certainty is very low.

1 finding from 1 review

Herbal mouthwash vs Blank control

Plaque · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

Herbal mouthwash reduced several plaque-related indices, but certainty is very low.

1 finding from 1 review

Herbal mouthwash vs Blank control

Gingival inflammation-related index · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

Herbal mouthwash reduced some gingival inflammation-related indices, but certainty is very low.

1 finding from 1 review

Herbal mouthwash vs Blank control

Cariogenic bacteria (Mutans streptococci) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)

Herbal mouthwash showed mixed effects on Mutans streptococci, with very low-certainty evidence.

1 finding from 1 review

Herbal extracts (tea components; Chinese herbal mixture; freeze-dried black raspberry gel) vs placebo or no treatment

Clinical resolution (oral lesion not completely resolved) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
  • SoF 4, Clinical resolution (not completely resolved) at 3 to 6 months: '3 studies (freeze-dried black raspberry gel, green tea extract capsules, mixed tea) did not find evidence of benefit.' No GRADE. Effects text:…
    4 studies
    GRADE not reported

Herbal extracts (tea components; Chinese herbal mixture; freeze-dried black raspberry gel) vs placebo or no treatment

Malignant transformation (oral cancer development) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
  • SoF 4 (Herbal extracts vs placebo), Cancer development: SoF cell 'Not measured'. Effects text: cancer development was among the outcomes in Tsao 2009 (green tea extract) but it was not possible to analyse the data…
    1 study
    GRADE not reported

Herbal extracts (tea components; Chinese herbal mixture; freeze-dried black raspberry gel) vs placebo or no treatment

Improvement of histological features (not improved) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
  • SoF 4, Histological changes (not improved) at 3 months: '2 studies (green tea extract capsules and freeze-dried raspberry gel) did not find evidence of benefit.' No GRADE. Effects text: Mallery raspberry RR 0.97…
    2 studies
    GRADE not reported

Herbal extracts (tea components; Chinese herbal mixture; freeze-dried black raspberry gel) vs placebo or no treatment

Safety of the intervention (adverse effects) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
  • Interventions for treating oral leukoplakia to prevent oral cancer 2016 · Cochrane All outcomes
    up to 3 months
    SoF 4, Safety of the intervention up to 3 months: '3 studies measured adverse effects: green tea extract capsules caused high frequency (93%) of adverse effects of varying severity in 1 study; the mixed tea study did…
    3 studies
    GRADE not reported

Pericarp extract of Garcinia mangostana L mouthrinse (herbal) vs placebo

Volatile sulphur compounds (VSC), halimeter · Adults over 18 years with a clinical or self-assessed diagnosis of halitosis, without significant comorbidity (e.g. diabetes) or…
1 finding from 1 review
  • Mouthrinses for the treatment of halitosis 2008 · Cochrane All outcomes
    15 days
    Rassameemasmaung 2007: halimeter-assessed VSC (ppb). Herbal (Garcinia mangostana L): 248.35 (SD 172.30) at baseline to 100.54 (SD 69.37) at day 15 (59.68% reduction, P < 0.05); Placebo: 237.45 (SD 114.15) to 176.83 (SD…
    1 study · 60 participants
    GRADE not reported

Single herb plus conventional intervention vs conventional intervention

Visual improvement at end of treatment, as defined by two or more Snellen lines · people with diabetic retinopathy

Single herb plus conventional intervention may leads to higher visual acuity (gain of ≥ 2 lines) (end of treatment) compared with conventional intervention (low certainty).

1 finding from 1 review

Chinese herbal medicines vs drugs

Total effectiveness rate with subgroup analysis ‐ individualised treatment Clinician's rating · atopic eczema

CHM may leads to higher total effectiveness rate with subgroup analysis ‐ individualised… compared with drugs (low certainty).

1 finding from 1 review

Chinese herbal medicines vs drugs

Total effectiveness rate with subgroup analysis ‐ non‐individualised treatment Clinician's rating · atopic eczema

It is very uncertain whether CHM changes total effectiveness rate with subgroup analysis ‐ non‐individualised… compared with drugs (very low certainty).

1 finding from 1 review