Oral health-related quality of life (child and family) · Preschool children in the United Arab Emirates receiving dental general anesthesia
One study found restorative dental treatment under general anesthesia significantly improved oral health-related quality of life for preschool children and their families (narrative synthesis; not GRADE-rated).
1 finding from 1 review
Alantali et al. found that restorative dental general anesthesia resulted in significant improvement in child and family physical, psychological and social quality-of-life, with a large change noted in both the child…
1 study
GRADE not reported
Treatment failure (annual failure rate) · Children with moderately deep dentine caries in primary molars, no pulp therapy
Etch-and-rinse adhesion failed more than self-etch (19.5% vs 7.0% annual failure) in one RCT; low quality of evidence (ungraded).
1 finding from 1 review
Enamel demineralization (DIAGNOdent score) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Adhesive precoated flash-free brackets showed no demineralization difference, with certainty not graded.
1 finding from 1 review
Intergroup evaluation showed that there were no statistically significant differences in demineralization measurements between all sides of the conventional and flash-free brackets at all the time intervals (p >0.05).
1 study · 30 participants
GRADE not reported
White spot lesion incidence, area, and depth · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
GC Ortho Connect had more frequent, larger, and deeper WSLs, with certainty not graded.
1 finding from 1 review
Group 3 (GC Ortho Connect) showed a significantly higher incidence than both groups (p < 0.001). Group 3 (GC Ortho Connect) also had larger lesion areas and deeper lesions compared to other groups (p < 0.001).
1 study · 75 participants
GRADE not reported
White spot lesion formation (QLF: fluorescence loss, lesion area) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Indirect bonding with a flowable adhesive favored less QLF-measured demineralization, with certainty not graded.
1 finding from 1 review
The DB group exhibited significantly higher loss of fluorescence and degree of demineralization compared to the IB group between T0 and T1, with notable differences in specific quadrants (p <0.05 for ΔF and ΔF max).
1 study · 51 participants
GRADE not reported
White spot lesion formation (QLF: fluorescence loss, lesion area) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)
A single RCT found indirect bonding with flowable composite reduced white spot lesion formation versus direct bonding (ungraded).
1 finding from 1 review
DMFT (association with plaque) · Children aged 5-6 years in Ajman schools
The highest plaque category was associated with higher dental caries.
1 finding from 1 review
Early childhood caries (ECC) · Children (approx. 4-18 years)
In the Region: Asian countries subgroup, the BMI (highest vs lowest)-childhood caries association was significant (OR 1.70, 95% CI 1.25 to 2.32; ungraded).
17 findings from 1 review
Show 14 more findings
Childhood obesity in relation to risk of dental caries: a cumulative and dose-response systematic review and… 2024 All outcomesDental examinations of children; 15 countries across Europe, Asia, the Americas and Oceania · Country population: large
OR 1.56 [1.09, 2.21]
9 studies
GRADE not reported
Childhood obesity in relation to risk of dental caries: a cumulative and dose-response systematic review and… 2024 All outcomesDental examinations of children; 15 countries across Europe, Asia, the Americas and Oceania · Age: 7-15 years
OR 1.25 [0.87, 1.81]
7 studies
GRADE not reported
Childhood obesity in relation to risk of dental caries: a cumulative and dose-response systematic review and… 2024 All outcomesDental examinations of children; 15 countries across Europe, Asia, the Americas and Oceania · Region: European countries
OR 0.81 [0.36, 1.81]
3 studies
GRADE not reported
Childhood obesity in relation to risk of dental caries: a cumulative and dose-response systematic review and… 2024 All outcomesDental examinations of children; 15 countries across Europe, Asia, the Americas and Oceania
OR 1.44 [1.16, 1.78]
16 studies
GRADE not reported
Childhood obesity in relation to risk of dental caries: a cumulative and dose-response systematic review and… 2024 All outcomesDental examinations of children; 15 countries across Europe, Asia, the Americas and Oceania · Study design: case-control
OR 1.31 [0.77, 2.22]
4 studies
GRADE not reported
Childhood obesity in relation to risk of dental caries: a cumulative and dose-response systematic review and… 2024 All outcomesDental examinations of children; 15 countries across Europe, Asia, the Americas and Oceania · Sample size: >900
OR 1.59 [1.25, 2.02]
8 studies
GRADE not reported
Childhood obesity in relation to risk of dental caries: a cumulative and dose-response systematic review and… 2024 All outcomesDental examinations of children; 15 countries across Europe, Asia, the Americas and Oceania · Adjustment for sex: yes
OR 1.30 [0.99, 1.71]
10 studies
GRADE not reported
Childhood obesity in relation to risk of dental caries: a cumulative and dose-response systematic review and… 2024 All outcomesDental examinations of children; 15 countries across Europe, Asia, the Americas and Oceania · Adjustment for sex: no
OR 1.74 [1.13, 2.68]
6 studies
GRADE not reported
Childhood obesity in relation to risk of dental caries: a cumulative and dose-response systematic review and… 2024 All outcomesDental examinations of children; 15 countries across Europe, Asia, the Americas and Oceania · Study design: cohort
OR 1.27 [1.07, 1.56]
3 studies
GRADE not reported
Childhood obesity in relation to risk of dental caries: a cumulative and dose-response systematic review and… 2024 All outcomesDental examinations of children; 15 countries across Europe, Asia, the Americas and Oceania · Country population: small
OR 1.31 [0.95, 1.81]
7 studies
GRADE not reported
Childhood obesity in relation to risk of dental caries: a cumulative and dose-response systematic review and… 2024 All outcomesDental examinations of children; 15 countries across Europe, Asia, the Americas and Oceania · Adjustment for age: no
OR 1.68 [1.29, 2.18]
10 studies
GRADE not reported
Childhood obesity in relation to risk of dental caries: a cumulative and dose-response systematic review and… 2024 All outcomesDental examinations of children; 15 countries across Europe, Asia, the Americas and Oceania · Region: American countries
OR 1.28 [0.91, 1.81]
7 studies
GRADE not reported
Childhood obesity in relation to risk of dental caries: a cumulative and dose-response systematic review and… 2024 All outcomesDental examinations of children; 15 countries across Europe, Asia, the Americas and Oceania · Sample size: <900
OR 1.25 [0.77, 2.02]
8 studies
GRADE not reported
Childhood obesity in relation to risk of dental caries: a cumulative and dose-response systematic review and… 2024 All outcomesDental examinations of children; 15 countries across Europe, Asia, the Americas and Oceania · Age: <7 years
OR 1.59 [1.22, 2.07]
9 studies
GRADE not reported
Proposed inhibition of S. mutans adhesion to tooth surface (mechanism; direct adherence endpoint confirmed only in Ahn 2018) · Cariogenic bacteria (mainly Streptococcus mutans reference strains) and oral biofilms in vitro
Postbiotics inhibit S. mutans adhesion to tooth surfaces in vitro (ungraded narrative synthesis).
1 finding from 1 review
Virulence-gene expression related to adhesion acid production and exopolysaccharide synthesis · Cariogenic bacteria (mainly Streptococcus mutans reference strains) and oral biofilms in vitro
No meta-analysis was conducted; the narrative synthesis reported reduced expression of Streptococcus mutans virulence genes.
1 finding from 1 review
Cariogenic and commensal oral bacteria (S. mutans and commensal streptococci growth, adhesion, biofilm) · Oral bacteria (streptococci), dental hard tissue (enamel/dentin) and e-liquids studied in vitro/ex vivo (with a few clinical microbiome…
Most in vitro studies indicate e-cigarette aerosol/e-liquid (especially flavored/high-concentration) disrupts normal oral flora and favors cariogenic S. mutans growth and biofilm, plausibly increasing caries risk; not pooled (ungraded, narrative).
1 finding from 1 review
Bacterial adhesion (inhibition) · Streptococcus mutans (in vitro cultures and biofilms)
Grape seed extract inhibits S. mutans adhesion to hydroxyapatite in vitro (2 studies; ungraded).
1 finding from 1 review
Bacterial adhesion or initial colonization · Streptococcus mutans (in vitro cultures and biofilms)
No meta-analysis was conducted; three included studies reported reduced adhesion or initial colonization with cranberry extract or fractions.
1 finding from 1 review
no estimate extracted
3 studies
GRADE not reported
Bacterial adhesion (inhibition) · Streptococcus mutans (in vitro cultures and biofilms)
Cranberry extract inhibits S. mutans adhesion / initial colonization in vitro (3 studies; ungraded).
1 finding from 1 review
Bacterial adhesion · Streptococcus mutans (in vitro cultures and biofilms)
No meta-analysis was conducted; two included studies reported reduced Streptococcus mutans adhesion with grape seed extract or fractions.
1 finding from 1 review
no estimate extracted
2 studies
GRADE not reported
Impaired OHRQoL measured with CPQ 11-14 (quantitative synthesis / meta-analysis) · Adolescents (10-19 years)
Malocclusion (DAI) probably increases the prevalence of impaired OHRQoL (CPQ 11-14) by about 15% in adolescents (RR/PR 1.15, 95% CI 1.12-1.18; moderate certainty).
1 finding from 1 review
Salivary flow rate · Elderly (>60 years) and medically compromised adults with xerostomia / dry mouth
Across 19 studies the effect of gum chewing on stimulated and/or unstimulated salivary flow rate was mixed (9 positive, 10 no effect); this broad outcome was not meta-analyzed.
1 finding from 1 review
The effect of gum chewing on xerostomia and salivary flow rate in elderly and medically compromised subjects: a… 2023 All outcomesVarious (single session to 12 months) · Haemodialysis units, elderly / geriatric care, cancer and palliative care, and xerostomia / hyposalivation clinics (studies from multiple countries)
Narrative vote-count: of 19 studies measuring stimulated and/or unstimulated saliva flow rate, 9 found a positive effect of gum chewing [17,18,22,24,27,35,36,38,39] and 10 detected no effect…
19 studies
GRADE not reported
Poor oral health-related quality of life (OHRQoL) · Adolescents (10-19 years)
Malocclusions probably have a negative effect on OHRQoL in adolescents, after adjustment for confounders (moderate certainty).
1 finding from 1 review
Impaired OHRQoL, qualitative synthesis: relative effect not estimable across the 13 studies (13,864 participants); moderate quality of evidence (GRADE).
13 studies · 13864 participants
Moderate
Enamel surface microhardness · Human enamel specimens around orthodontic brackets (in vitro)
In vitro, a nano-hydroxyapatite-containing orthodontic composite showed significant enamel remineralization versus control in a single study (ungraded).
1 finding from 1 review
Streptococcus mutans count · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)
The antibacterial (S. mutans) effect of TiO2 nanoparticles was conflicting across two RCTs (ungraded).
1 finding from 1 review