Findings

What do systematic reviews say?

85 questions · 85 findings · 15 reviews · Headline outcomes only

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No studies found 18 · 21.2%GRADE not reported 0 · 0%Very low 28 · 32.9%Low 19 · 22.4%Moderate 17 · 20%High 3 · 3.5%

Gabapentin vs placebo

At least 30% reduction in pain · adults with fibromyalgia

1 finding from 1 review

Gabapentin for fibromyalgia pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 150 participants
Very low

Gabapentin vs placebo

At least 50% reduction in pain · adults with fibromyalgia

1 finding from 1 review

Gabapentin for fibromyalgia pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Gabapentin vs placebo

PGIC ‐ any category of "better" at 12 weeks · adults with fibromyalgia

1 finding from 1 review

Gabapentin for fibromyalgia pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 150 participants
Very low

Gabapentin vs placebo

Withdrawals due to adverse events · adults with fibromyalgia

1 finding from 1 review

Gabapentin for fibromyalgia pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 150 participants
Very low

Gabapentin vs placebo

Serious adverse events · adults with fibromyalgia

1 finding from 1 review

Gabapentin for fibromyalgia pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 150 participants
Very low

Gabapentin vs placebo

Deaths · adults with fibromyalgia

1 finding from 1 review

Gabapentin for fibromyalgia pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 150 participants
Very low

Gabapentin vs cetirizine (antihistamine)

Change in burn‐related pruritus (VAS) ( · people with postburn pruritus

Gabapentin showed no clear difference in change in burn‐related pruritus (VAS) ( compared with cetirizine (antihistamine) (low certainty).

1 finding from 1 review

Interventions for postburn pruritus 2024 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Low

Gabapentin vs cetirizine (antihistamine)

Somnolence · people with postburn pruritus

Gabapentin may leads to lower adverse events (somnolence) compared with cetirizine (antihistamine) (low certainty).

1 finding from 1 review

Interventions for postburn pruritus 2024 · Cochrane Headline outcomes only
RR 0.02 [0, 0.38]
1 study · 40 participants
Low

Gabapentin vs cetirizine (antihistamine)

Pain · people with postburn pruritus

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for postburn pruritus 2024 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Gabapentin vs placebo

Severity of PTSD symptoms ‐ Clinician‐rated · adults (aged 18 and older) exposed to a traumatic event

1 finding from 1 review

Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1 participants
Very low

Gabapentin vs placebo

Dropouts due to adverse events · adults (aged 18 and older) exposed to a traumatic event

The review found no eligible studies for this question.

1 finding from 1 review

Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Gabapentin vs placebo

PTSD rate at 3 months · adults (aged 18 and older) exposed to a traumatic event

It is very uncertain whether gabapentin changes PTSD rate at 3 months compared with placebo (very low certainty).

1 finding from 1 review

Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
RR 0.8 [0.18, 3.59]
1 study · 26 participants
Very low

Gabapentin vs placebo

Functional disability at 3 months ‐ not measured · adults (aged 18 and older) exposed to a traumatic event

The review found no eligible studies for this question.

1 finding from 1 review

Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Gabapentin vs placebo

Quality of life at 3 months ‐ not measured · adults (aged 18 and older) exposed to a traumatic event

The review found no eligible studies for this question.

1 finding from 1 review

Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Gabapentin vs amitriptyline

Participant‐reported pain relief of 30% or greater · children and adolescents with chronic non‐cancer pain

The review found no eligible studies for this question.

1 finding from 1 review

Antiepileptic drugs for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Gabapentin vs amitriptyline

Participant‐reported pain relief of 50% or greater · children and adolescents with chronic non‐cancer pain

The review found no eligible studies for this question.

1 finding from 1 review

Antiepileptic drugs for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Gabapentin vs amitriptyline

Patient Global Impression of Change much or very much improved · children and adolescents with chronic non‐cancer pain

The review found no eligible studies for this question.

1 finding from 1 review

Antiepileptic drugs for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Gabapentin vs amitriptyline

Any adverse events · children and adolescents with chronic non‐cancer pain

1 finding from 1 review

Antiepileptic drugs for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 34 participants
Very low

Gabapentin vs amitriptyline

Serious adverse events · children and adolescents with chronic non‐cancer pain

1 finding from 1 review

Antiepileptic drugs for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 34 participants
Very low

Gabapentin vs amitriptyline

Withdrawals due to adverse events · children and adolescents with chronic non‐cancer pain

1 finding from 1 review

Antiepileptic drugs for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 34 participants
Very low