Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

219 questions · 351 findings · 32 reviews

No studies found 17 · 4.8%GRADE not reported 270 · 76.9%Very low 20 · 5.7%Low 37 · 10.5%Moderate 5 · 1.4%High 2 · 0.6%

Early childhood caries (ECC) vs Caries-free controls

Relative abundance of Veillonella spp. · Young children with early childhood caries and caries-free controls

Veillonella spp. mean relative abundance was higher in ECC children, without a comparative effect estimate or CI.

4 findings from 2 reviews · compare the 2 reviews
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Early childhood caries (ECC) vs Caries-free controls

Number of detected salivary bacterial genera · Young children with early childhood caries and caries-free controls

Fewer salivary bacterial genera were reported in the caries-affected group, without a comparative effect estimate or CI.

1 finding from 1 review

Early childhood caries (ECC) vs Caries-free controls

Relative abundance of dominant salivary microbial community (7 genera) · Young children with early childhood caries and caries-free controls

The reported multi-genus community had similar relative abundance in caries-affected and caries-free children, without a comparative effect estimate or CI.

1 finding from 1 review

Early childhood caries (ECC) vs Caries-free controls

Streptococcus mutans and Veillonella spp. levels · Young children with early childhood caries and caries-free controls

Veillonella spp. levels were reported as substantially greater in caries subjects, but the review gave no numerical effect estimate or CI.

1 finding from 1 review

Early childhood caries (ECC) vs NA (within-white-spot-lesion correlation, not a caries vs caries-free comparison)

Correlation of Veillonella spp. with acidogenic streptococci · Young children with early childhood caries and caries-free controls

Veillonella spp. levels were correlated with acidogenic streptococci in white spot lesions (r²=0.38); no CI was reported.

1 finding from 1 review

Severe early childhood caries vs Caries-free controls

Relative abundance of Veillonella spp. · Children under 6 years with severe early childhood caries and caries-free controls

Veillonella spp. mean relative abundance was lower in the S-ECC group; no comparative effect estimate or CI was reported.

1 finding from 1 review

Severe early childhood caries vs Caries-free controls

Relative abundance of S. mutans in saliva · Children under 6 years with severe early childhood caries and caries-free controls

S. mutans median relative abundance was higher in the S-ECC group, without a comparative effect estimate or CI.

1 finding from 1 review

Severe early childhood caries vs Caries-free controls

Streptococcus relative abundance · Children under 6 years with severe early childhood caries and caries-free controls

Streptococcus mean relative abundance was slightly higher in the S-ECC group; no comparative effect estimate or CI was reported.

1 finding from 1 review

Severe early childhood caries vs Caries-free controls

Veillonella spp. and Streptococcus mutans interaction · Children under 6 years with severe early childhood caries and caries-free controls

The study reported a possible role for Veillonella spp. in supporting cariogenic species, without a quantitative effect estimate.

1 finding from 1 review

Severe early childhood caries vs Caries-free controls

Veillonella dispar relative abundance · Children under 6 years with severe early childhood caries and caries-free controls

Veillonella dispar median relative abundance was higher in the S-ECC group, without a comparative effect estimate or CI.

1 finding from 1 review

Not applicable (single-group prevalence) vs Not applicable (single-group prevalence)

Early childhood caries (ECC) · Children aged 0-5 years in North Africa

Pooled ECC prevalence in Tunisia was 38% (95% CI 24-51), significantly lower than Egypt and Sudan.

10 findings from 1 review
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Higher parental education (tertiary) vs Lower parental education (reference)

Early childhood caries (ECC) · Children aged 0-5 years in North Africa

Paternal tertiary education was associated with lower odds of ECC (OR 0.381).

3 findings from 1 review

Brushing vs Brushing less than daily

Early childhood caries (ECC) · Children aged 0-5 years in North Africa

Brushing twice daily was associated with lower odds of ECC (OR 0.033).

2 findings from 1 review

Sugar consumption (higher sugar intake) vs No sugar consumption (lower/no intake)

Early childhood caries (ECC) · Preschool children (<6 years)

Higher sugar consumption is associated with early childhood caries in children under 6 years: pooled OR 1.59 (95% CI 1.50 to 1.68) from 9 cohort studies with no heterogeneity (I2=0%); the body of evidence was not GRADE-rated (ungraded).

1 finding from 1 review

Older child age (months) vs Younger age (reference)

Early childhood caries (ECC) · Children aged 0-5 years in North Africa

Age 48-59 months was associated with higher odds of ECC (OR 2.602).

2 findings from 1 review

Timing of first dental visit vs Reference visit timing

Early childhood caries (ECC) · Children aged 0-5 years in North Africa

An early first dental visit was associated with much lower odds of ECC (OR 0.042).

2 findings from 1 review