Number of detected salivary bacterial genera · Young children with early childhood caries and caries-free controls
Fewer salivary bacterial genera were reported in the caries-affected group, without a comparative effect estimate or CI.
1 finding from 1 review
Relative abundance of dominant salivary microbial community (7 genera) · Young children with early childhood caries and caries-free controls
The reported multi-genus community had similar relative abundance in caries-affected and caries-free children, without a comparative effect estimate or CI.
1 finding from 1 review
Streptococcus mutans and Veillonella spp. levels · Young children with early childhood caries and caries-free controls
Veillonella spp. levels were reported as substantially greater in caries subjects, but the review gave no numerical effect estimate or CI.
1 finding from 1 review
Correlation of Veillonella spp. with acidogenic streptococci · Young children with early childhood caries and caries-free controls
Veillonella spp. levels were correlated with acidogenic streptococci in white spot lesions (r²=0.38); no CI was reported.
1 finding from 1 review
Relative abundance of Veillonella spp. · Children under 6 years with severe early childhood caries and caries-free controls
Veillonella spp. mean relative abundance was lower in the S-ECC group; no comparative effect estimate or CI was reported.
1 finding from 1 review
Relative abundance of S. mutans in saliva · Children under 6 years with severe early childhood caries and caries-free controls
S. mutans median relative abundance was higher in the S-ECC group, without a comparative effect estimate or CI.
1 finding from 1 review
Streptococcus relative abundance · Children under 6 years with severe early childhood caries and caries-free controls
Streptococcus mean relative abundance was slightly higher in the S-ECC group; no comparative effect estimate or CI was reported.
1 finding from 1 review
Veillonella spp. and Streptococcus mutans interaction · Children under 6 years with severe early childhood caries and caries-free controls
The study reported a possible role for Veillonella spp. in supporting cariogenic species, without a quantitative effect estimate.
1 finding from 1 review
Veillonella spp. may promote proliferation or survival of cariogenic species, as shown for interactions between Veillonella spp. and S. mutans.
1 study · 82 participants
GRADE not reported
Veillonella dispar relative abundance · Children under 6 years with severe early childhood caries and caries-free controls
Veillonella dispar median relative abundance was higher in the S-ECC group, without a comparative effect estimate or CI.
1 finding from 1 review
Caries arrest · Children with dentine carious lesions (ICDAS 4-5) in primary teeth
Twice-yearly 38% SDF was reported to arrest more caries than once-yearly application (24-month rates 91% vs 79%; ungraded).
1 finding from 1 review
Hemoglobin (Hb) level at the end of the study · Preschool children (<6 years)
Hemoglobin levels were significantly lower in children with ECC than in caries-free children (mean difference -9.96, 95% CI -15.45 to -4.46); ungraded.
1 finding from 1 review
Iron deficiency (as defined by trialists) · Preschool children (<6 years)
In a sensitivity analysis excluding one outlier study, ECC remained associated with higher odds of iron deficiency (OR 2.76, 95% CI 2.42 to 3.13); ungraded.
2 findings from 1 review
Iron deficiency anaemia · Preschool children (<6 years)
Children with early childhood caries were more likely to have iron-deficiency anemia than caries-free children (OR 2.74, 95% CI 2.41 to 3.11); ungraded.
1 finding from 1 review
Serum ferritin (ng/mL) · Preschool children (<6 years)
Serum ferritin levels did not differ significantly between children with ECC and caries-free children (mean difference -5.80, 95% CI -11.97 to 0.37); ungraded.
1 finding from 1 review
Mean corpuscular volume (MCV) · Preschool children (<6 years)
Mean corpuscular volume was significantly lower in children with ECC than in caries-free children (mean difference -3.72, 95% CI -6.65 to -0.79); ungraded.
1 finding from 1 review
Remineralization/arrest of early enamel carious lesions · Patients with early enamel carious lesions on permanent molars
For early enamel lesions, annual SDF+KI was significantly LESS effective than twice-daily tricalcium silicate paste (54.8% vs 100% arrested; p<0.001; ungraded).
1 finding from 1 review
Remineralization/arrest of early enamel carious lesions · Patients with early enamel carious lesions on permanent molars
For early enamel lesions, annual SDF+KI was significantly less effective than twice-daily CPP-ACP (54.8% vs 100% arrested; p<0.001; ungraded).
1 finding from 1 review
Remineralisation of early enamel caries · Patients (mainly children) with white spot lesions (WSL)
Professionally applied 5% sodium fluoride varnish remineralised about two-thirds of early enamel caries lesions in children (pooled proportion 63.6%, 95% CI 36.0% to 91.2%; 4 studies); certainty was not GRADE-rated and heterogeneity was very high (I2=96%).
1 finding from 1 review
Dimensional change (size) of early enamel caries lesions · Patients (mainly children) with white spot lesions (WSL)
In one trial, professionally applied sodium fluoride varnish significantly reduced the size of early enamel caries lesions compared with no fluoride treatment; ungraded.
1 finding from 1 review
Remineralisation of early enamel caries · Children with early (incipient) enamel caries
One trial found acidulated phosphate fluoride gel did not remineralise early enamel caries; ungraded.
1 finding from 1 review