Side effects · Adults, 16 years and older (dentate)
1 finding from 1 review
Side effects · Adults, 16 years and older (dentate)
1 finding from 1 review
Three studies reported that there were no adverse events, one reported one incidence of aphthous ulcer in irrigator group, one reported oral lacerations but found no difference between the interventions, and one did…
5 studies
GRADE not reported
Side effects · Adults, 16 years and older (dentate)
The review found no eligible studies for this question.
1 finding from 1 review
Side effects · Adults, 16 years and older (dentate)
The review found no eligible studies for this question.
1 finding from 1 review
Visual inspection scores · Patients with early caries lesions in permanent teeth (non-fluoridated water area)
Two trials reported visual inspection scores but could not be pooled (different criteria, missing standard deviations) and gave inconsistent findings, so no quantitative conclusion could be drawn.
1 finding from 1 review
Side effects · Dentate adults aged 16 years or older (excluding orthodontic patients and those with severe periodontal disease)
1 finding from 1 review
Not estimable (5 studies). Adverse effects were assessed in five studies, but they used different outcome measures, so meta-analysis was not appropriate. The main harm identified was soft-tissue trauma to the gingival…
5 studies
GRADE not reported
Adverse effects (tooth staining and other side effects) · Children and adolescents aged 16 years or less
1 finding from 1 review
Adverse effects: dental fluorosis · Children and adolescents aged 16 years or less
The review found no eligible studies for this question.
1 finding from 1 review
Development of >=1 new carious lesion (caries incidence) · Caries-free children to young adults with premolars/molars requiring pit-and-fissure sealants
In the single study reporting it, caries incidence was 0% in both the laser-alone and acid-etching groups (ungraded, single study).
1 finding from 1 review
Karaman 2013 (Er,Cr:YSGG laser vs acid-etching): incidence of caries was 0% in both groups; not meta-analyzed.
1 study · 16 participants
GRADE not reported
Acceptability · Caries-free children to young adults with premolars/molars requiring pit-and-fissure sealants
Both laser and acid-etching preparation were well accepted by patients (VAS, P = 1.000; ungraded, single study).
1 finding from 1 review
Kumar 2016 (Er,Cr:YSGG laser vs acid-etching): patient acceptance scored on a visual analogue scale; both preparations well accepted, P = 1.000; no significant difference.
1 study · 50 participants
GRADE not reported
Clinical (chair-side) time · Caries-free children to young adults with premolars/molars requiring pit-and-fissure sealants
Laser conditioning was reported to take less chair-side time than acid-etching in the studies that measured it, but times were not pooled (ungraded, narrative).
1 finding from 1 review
Walsh 1996 reported laser conditioning time of 7 s vs 70 s for acid preparation; Kumar 2016 reported Er,Cr:YSGG exposure ~10 s vs >35 s for acid etching; laser conditioning was shorter but times were not pooled, and…
2 studies
GRADE not reported
Sealant retention rate (completely retained) · Caries-free children to young adults with premolars/molars requiring pit-and-fissure sealants
At 18 months, laser preparation alone did not differ significantly from acid-etching for sealant retention (OR 0.82, 95% CI 0.23 to 2.85; ungraded, single study, high risk of bias).
6 findings from 1 review
OR 0.82 [0.23, 2.85]
1 study · 16 participants
GRADE not reported
OR 1.22 [0.69, 2.16]
3 studies · 80 participants
GRADE not reported
OR 1.05 [0.61, 1.80]
3 studies · 73 participants
GRADE not reported
Show 3 more findings
OR 2.78 [0.87, 8.91]
2 studies · 65 participants
GRADE not reported
OR 1.15 [0.63, 2.10]
1 study · 43 participants
GRADE not reported
OR 0.87 [0.31, 2.45]
1 study · 16 participants
GRADE not reported
Enamel remineralization extent · Human enamel specimens around orthodontic brackets (in vitro)
In vitro, a nano-CaF2-containing orthodontic cement showed significant enamel remineralization versus control in a single study (ungraded).
1 finding from 1 review
Intervention not reported
Pit-and-fissure caries progression (ICDAS), CO2 laser vs fluoride varnish alone
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Enamel demineralization (QLF ΔF) · Human enamel specimens under cariogenic challenge (in situ / ex vivo)
Evidence on a synergistic effect of combining CO2 laser with fluoride versus fluoride alone is mixed: one ex-vivo study found combined treatment superior while another found no synergy (ungraded, 2 ex-vivo studies, no pooled estimate).
1 finding from 1 review
COE with blood/salivary (biomarker) analysis vs Conventional oral examination (COE) alone
Outcome not reported · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance programme, or screened…
The review found no eligible studies for this question.
1 finding from 1 review
Sensitivity · Oral cavity cancer or potentially malignant disorder symptom-free individuals with tobacco habits
1 finding from 1 review
Whitening (bleaching) efficacy · Demineralised / white-spot-lesion enamel (in vitro specimens)
Low-quality in vitro evidence indicates that adding fluoride or other remineralising agents does not impair the whitening/bleaching effect (ungraded).
1 finding from 1 review
Enamel mineral loss / remineralisation · Demineralised / white-spot-lesion enamel (in vitro specimens)
Low-quality in vitro evidence indicates that adding fluoride, calcium or CPP-ACP to bleaching agents can reduce enamel mineral loss (ungraded).
1 finding from 1 review
Sealant retention rate (completely retained) · Children with permanent molars requiring pit-and-fissure sealants
At 12 months, Er:YAG laser combined with acid-etching significantly improved sealant retention versus acid-etching alone (OR 0.39, 95% CI 0.19 to 0.80, favouring laser+acid; ungraded, single study).
4 findings from 1 review
OR 0.39 [0.19, 0.80]
1 study · 42 participants
GRADE not reported
OR 0.55 [0.23, 1.34]
1 study · 42 participants
GRADE not reported
OR 0.41 [0.21, 0.80]
1 study · 42 participants
GRADE not reported
Show 1 more finding