Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,696 questions · 3,815 findings · 855 reviews

No studies found 573 · 15%GRADE not reported 374 · 9.8%Very low 993 · 26%Low 1,062 · 27.8%Moderate 614 · 16.1%High 199 · 5.2%

Mild clobetasol propionate cream regimen (10 to 30 g/day) vs standard clobetasol propionate cream regimen (40 g/day)

Disease control (healing of skin lesions) at day 21 · bullous pemphigoid

Mild clobetasol propionate cream regimen (10 to 30 g/day) showed no clear difference in disease control (healing of skin lesions) at day 21.… compared with standard clobetasol propionate cream regimen (40 g/day) (moderate certainty).

1 finding from 1 review

Rofecoxib (oral, 50 mg on first day then 25 to 50 mg per day for 4 days) vs Tinidazole (1 g per day for 3 days)

Total effective rate at 4 days · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Rofecoxib (oral, 50 mg on first day then 25 to 50 mg per day for 4… showed no clear difference in total effective rate at 4 days compared with tinidazole (1 g per day for 3 days); GRADE not reported.

1 finding from 1 review

Bamlanivimab vs placebo

Clinical progression: need for NIV, IMV, ECMO, or renal replacement therapy at day 5 (group 5, 6 or 7) · hospitalised individuals with COVID‐19 (moderate to severe disease)

It is very uncertain whether bamlanivimab changes clinical progression: need for NIV, IMV, ECMO, or renal replacement… compared with placebo (very low certainty).

1 finding from 1 review

Cooling treatment (ice pack) vs no treatment

Adverse effects on perineal wound healing: Day 5 ‐ Wound not healing · Women with perineal trauma (tear or episiotomy, or both) sustained during childbirth

It is very uncertain whether cooling treatment (ice pack or cold gel pad) changes adverse effects on perineal wound healing: Day 5 ‐ Wound not healing compared with no treatment (very low certainty).

1 finding from 1 review

Cooling treatment (ice pack) vs no treatment

Adverse effects on perineal wound healing: Day 5 ‐ Wound edges gaping · Women with perineal trauma (tear or episiotomy, or both) sustained during childbirth

It is very uncertain whether cooling treatment (ice pack or cold gel pad) changes adverse effects on perineal wound healing: Day 5 ‐ Wound edges gaping compared with no treatment (very low certainty).

1 finding from 1 review

Cooling treatment (ice pack) vs cooling treatment (cold gel pad)

Adverse effects on perineal wound healing: Day 5 ‐ Wound not healing · Women with perineal trauma (tear or episiotomy, or both) sustained during childbirth

It is very uncertain whether cooling treatment (ice pack) changes adverse effects on perineal wound healing: Day 5 ‐ Wound not healing compared with cooling treatment (cold gel pad) (very low certainty).

1 finding from 1 review

Cooling treatment (ice pack) vs cooling treatment (cold gel pad)

Adverse effects on perineal wound healing: Day 5 ‐ Wound edges gaping · Women with perineal trauma (tear or episiotomy, or both) sustained during childbirth

It is very uncertain whether cooling treatment (ice pack) changes adverse effects on perineal wound healing: Day 5 ‐ Wound edges gaping compared with cooling treatment (cold gel pad) (very low certainty).

1 finding from 1 review

Cooling treatment (ice pack) vs cooling treatment (cold gel pad)

Maternal views and experiences with treatment ‐ Opinion on treatment effects (good + very good + excellent) Day 5 · Women with perineal trauma (tear or episiotomy, or both) sustained during childbirth

It is very uncertain whether cooling treatment (ice pack) changes maternal views and experiences with treatment ‐ Opinion on treatment… compared with cooling treatment (cold gel pad) (very low certainty).

1 finding from 1 review

Intervention not reported

Stratum corneum hydration (SCH) (at baseline and day 56 ± 4) Hahnel 2017: measured at 56 ± 4 days in mid‐volar arm and lower leg in arbitrary units from 0 (no water) to 120 (on water) using the Corneometer CM 825 Gillis 2016: measured at 12 weeks ... · people 60 years of age and older
1 finding from 1 review

Intervention not reported

Clinical score of dryness Hahnel 2017: measured at day 56 ± 4 using the Overall Dry Skin Score Boccanfuso 1978: measured after 10 applications using a non‐validated General Foot Condition Questionnaire including a Dryness Scale (1 = oily; 2 = norm... · people 60 years of age and older
1 finding from 1 review

Single dose primaquine at 0.75 mg/kg vs no primaquine, with non‐artemisinin partner,

Participants infectious at day 8 · adults and children with malaria being treated with non‐artemisinin treatment

It is very uncertain whether single dose primaquine at 0.75 mg/kg changes participants infectious at day 5 compared with no primaquine, with non‐artemisinin partner, (very low certainty).

2 findings from 1 review

Single dose primaquine at 0.75 mg/kg vs no primaquine, with non‐artemisinin partner,

Participants with gametocytes at day 5, by microscopy · adults and children with malaria being treated with non‐artemisinin treatment

Single dose primaquine at 0.75 mg/kg showed no clear difference in participants with gametocytes at day 5, by microscopy compared with no primaquine, with non‐artemisinin partner, (low certainty).

1 finding from 1 review