Cochrane · systematic review · CD009555
Clozapine dose for schizophrenia
Subramanian, S, Völlm, BA, Huband, N · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
SchizophreniaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 15 · 71.4%Very low 2 · 9.5%Low 4 · 19%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Clozapine: very low dose (up to 149 mg/day) versus low dose (150 mg/day to 300 mg/day) for schizophrenia
Population: patients with schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Global state: clinically important response, as defined by individual studies Clozapine: very low dose (up to 149 mg/day) vs low dose (150 mg/day to 300 mg/day) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Mental state: clinically important response, as defined by individual studies * Clozapine: very low dose (up to 149 mg/day) vs low dose (150 mg/day to 300 mg/day) | no estimate extracted | 1 study · 31 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Functioning: clinically important change in general functioning, as defined by individual studies Clozapine: very low dose (up to 149 mg/day) vs low dose (150 mg/day to 300 mg/day) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Adverse effect: clinically important adverse effect (weight ‐ BMI) Clozapine: very low dose (up to 149 mg/day) vs low dose (150 mg/day to 300 mg/day) | no estimate extracted | 1 study · 59 participants | Low Downgraded: imprecision, indirectness |
Service use: number of days hospitalised Clozapine: very low dose (up to 149 mg/day) vs low dose (150 mg/day to 300 mg/day) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Service use: time to hospitalisation Clozapine: very low dose (up to 149 mg/day) vs low dose (150 mg/day to 300 mg/day) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Quality of life: clinically important change in general quality of life Clozapine: very low dose (up to 149 mg/day) vs low dose (150 mg/day to 300 mg/day) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Clozapine: very low dose (up to 149 mg/day) versus standard dose (301 mg/day to 600 mg/day) for schizophrenia
Population: patients with schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Global state: clinically important response, as defined by individual studies Clozapine: very low dose (up to 149 mg/day) vs standard dose (301 mg/day to 600 mg/day) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Mental state: clinically important response, as defined by individual studies * Clozapine: very low dose (up to 149 mg/day) vs standard dose (301 mg/day to 600 mg/day) | no estimate extracted | 1 study · 31 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Functioning: clinically important change in general functioning, as defined by individual studies Clozapine: very low dose (up to 149 mg/day) vs standard dose (301 mg/day to 600 mg/day) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Adverse effect: clinically important adverse effect (weight ‐ BMI) Clozapine: very low dose (up to 149 mg/day) vs standard dose (301 mg/day to 600 mg/day) | no estimate extracted | 1 study · 58 participants | Low Downgraded: imprecision, indirectness |
Service use: number of days hospitalised Clozapine: very low dose (up to 149 mg/day) vs standard dose (301 mg/day to 600 mg/day) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Service use: time to hospitalisation Clozapine: very low dose (up to 149 mg/day) vs standard dose (301 mg/day to 600 mg/day) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Quality of life: clinically important change in general quality of life Clozapine: very low dose (up to 149 mg/day) vs standard dose (301 mg/day to 600 mg/day) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Clozapine: low dose (150 mg/day to 300 mg/day) versus standard dose (301 mg/day to 600 mg/day) for schizophrenia
Population: patients with schizophrenia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Global state: clinically important response, as defined by individual studies Clozapine: low dose (150 mg/day to 300 mg/day) vs standard dose (301 mg/day to 600 mg/day) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Mental state: clinically important response in mental state BPRS score >30% change Clozapine: low dose (150 mg/day to 300 mg/day) vs standard dose (301 mg/day to 600 mg/day) | RR 0.93 [0.78, 1.1] | 1 study · 176 participants | Low Downgraded: risk of bias |
Functioning: clinically important change in general functioning, as defined by individual studies Clozapine: low dose (150 mg/day to 300 mg/day) vs standard dose (301 mg/day to 600 mg/day) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Adverse effect: clinically important adverse effect ( weight ‐ BMI) Clozapine: low dose (150 mg/day to 300 mg/day) vs standard dose (301 mg/day to 600 mg/day) | no estimate extracted | 1 study · 57 participants | Low Downgraded: indirectness |
Service use: number of days hospitalised Clozapine: low dose (150 mg/day to 300 mg/day) vs standard dose (301 mg/day to 600 mg/day) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Service use: time to hospitalisation Clozapine: low dose (150 mg/day to 300 mg/day) vs standard dose (301 mg/day to 600 mg/day) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Quality of life: clinically important change in general quality of life Clozapine: low dose (150 mg/day to 300 mg/day) vs standard dose (301 mg/day to 600 mg/day) | no estimate extracted | 0 studies · 0 participants | Ungraded |