Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

38 questions · 38 findings · 7 reviews

No studies found 3 · 7.9%GRADE not reported 1 · 2.6%Very low 10 · 26.3%Low 10 · 26.3%Moderate 12 · 31.6%High 2 · 5.3%

Oral + inhaled dual therapy vs oral monotherapy

Microbiological response: eradicated. Outcome assessed on day 21 · bronchiectasis

It is very uncertain whether oral + inhaled dual therapy changes microbiological response: eradicated. Outcome assessed on day 21 compared with oral monotherapy (very low certainty).

1 finding from 1 review

G‐CSF + standard treatment vs usual care

improvement of infection clinical and microbiological assessment · patients with diabetic foot infection

G‐CSF + standard treatment may leads to higher improvement of infection clinical and microbiological assessment compared with usual treatment (low certainty).

1 finding from 1 review

Levofloxacin vs ciprofloxacin

Microbiological efficacy ‐ pathogen eradication · patients with chronic bacterial prostatitis

It is very uncertain whether levofloxacin changes microbiological efficacy ‐ pathogen eradication compared with ciprofloxacin (very low certainty).

1 finding from 1 review

Levofloxacin vs fluoroquinolones

Microbiological efficacy ‐ pathogen eradication · patients with chronic bacterial prostatitis

It is very uncertain whether levofloxacin changes microbiological efficacy ‐ pathogen eradication compared with comparator fluoroquinolone (very low certainty).

1 finding from 1 review

Lomefloxacin vs fluoroquinolones

Microbiological efficacy ‐ pathogen eradication · patients with chronic bacterial prostatitis

Lomefloxacin showed no clear difference in microbiological efficacy ‐ pathogen eradication at compared with comparator fluoroquinolone (low certainty).

1 finding from 1 review

Ciprofloxacin vs fluoroquinolones

Microbiological efficacy ‐ pathogen eradication · patients with chronic bacterial prostatitis

It is very uncertain whether ciprofloxacin changes microbiological efficacy ‐ pathogen eradication at end of treatment compared with comparator fluoroquinolone (very low certainty).

1 finding from 1 review

Ciprofloxacin vs placebo added to cycled and culture‐based inhaled tobramycin (TNS) therapy

Eradication of P aeruginosa from the respiratory tract: proportion of participants with one or more isolates of P aeruginosa from the respiratory tract · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

The review found no eligible studies for this question.

1 finding from 1 review

Ciprofloxacin vs placebo added to cycled and culture‐based inhaled tobramycin (TNS) therapy

Pulmonary exacerbations · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

Ciprofloxacin showed no clear difference in frequency of infective pulmonary exacerbations: proportion of… compared with placebo added to cycled and culture‐based inhaled tobramycin (TNS)… (moderate certainty).

1 finding from 1 review

Ciprofloxacin vs placebo added to cycled and culture‐based inhaled tobramycin (TNS) therapy

Isolation of other micro‐organisms from the respiratory tract: proportion of participants with new isolates of Stenotrophomonas maltophilia · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

Ciprofloxacin showed no clear difference in isolation of other micro‐organisms from the respiratory tract:… compared with placebo added to cycled and culture‐based inhaled tobramycin (TNS)… (moderate certainty).

1 finding from 1 review

Ciprofloxacin vs placebo added to cycled and culture‐based inhaled tobramycin (TNS) therapy

Adverse effects of antibiotics: proportion of participants with one or more serious adverse event · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

Ciprofloxacin showed no clear difference in adverse effects of antibiotics: proportion of participants with one… compared with placebo added to cycled and culture‐based inhaled tobramycin (TNS)… (moderate certainty).

1 finding from 1 review