Cochrane · systematic review · CD006810
Granulocyte‐colony stimulating factors as adjunctive therapy for diabetic foot infections
Cruciani, M, Lipsky, BA, Mengoli, C, et al. · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
WoundsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
3
current version
GRADE rated
3
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 100%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
G‐CSF + standard treatment compared to usual treatment for diabetic foot infection
Population: patients with diabetic foot infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
improvement of infection clinical and microbiological assessment G‐CSF + standard treatment vs usual treatment | RR 1.4 [1.06, 1.85] | 4 studies · 140 participants | Low Downgraded: risk of bias |
Need for surgery: Overall Surgical Interventions G‐CSF + standard treatment vs usual treatment | RR 0.37 [0.2, 0.68] | 5 studies · 167 participants | Low Downgraded: risk of bias |
Need for surgery: Amputation G‐CSF + standard treatment vs usual treatment | RR 0.41 [0.18, 0.95] | 5 studies · 167 participants | Low Downgraded: risk of bias |