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Evidence found and GRADE certainty

107 questions · 108 findings · 7 reviews

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No studies found 30 · 27.8%GRADE not reported 6 · 5.6%Very low 15 · 13.9%Low 41 · 38%Moderate 12 · 11.1%High 4 · 3.7%

Antihistamines vs placebo

Adverse effects: 1. Sedation · patients with motion sickness

Antihistamines may leads to higher adverse effects: sedation Assessed by: adverse effect questionnaire… compared with placebo (low certainty).

1 finding from 1 review

Antihistamines vs placebo

Adverse effects: impaired cognition Assessed by: adverse effect questionnaire (presence or absence given numerical values) · patients with motion sickness

Antihistamines showed no clear difference in adverse effects: impaired cognition Assessed by: adverse effect… compared with placebo (low certainty).

1 finding from 1 review

Antihistamines vs placebo

Adverse effects ‐ Blurred vision No of patients with blurred vision · patients with motion sickness

Antihistamines showed no clear difference in adverse effects: blurred vision Assessed by: adverse effect… compared with placebo (low certainty).

1 finding from 1 review

Antihistamines vs scopolamine

Proportion of susceptible participants who did not experience any motion sickness symptoms under natural conditions Assessed by: self‐reported questionnaires6,7 · patients with motion sickness

It is very uncertain whether antihistamines changes proportion of susceptible participants who did not experience any… compared with scopolamine (very low certainty).

1 finding from 1 review

Antihistamines vs placebo

Change in severity of overall symptoms: short‐term (1 to 2 days) Subjective severity score · patients with common cold

Antihistamines probably leads to lower change in severity of overall symptoms: short‐term Subjective… compared with placebo (moderate certainty).

1 finding from 1 review

Antihistamines vs placebo

Change in severity of overall symptoms: intermediate‐term (3 to 4 days) Subjective severity score · patients with common cold

Antihistamines showed no clear difference in change in severity of overall symptoms: intermediate‐term (3 to 4… compared with placebo (high certainty).

1 finding from 1 review

Antihistamines vs placebo

Change in severity of overall symptoms: long‐term (6 to 10 days) Subjective severity score · patients with common cold

Antihistamines showed no clear difference in change in severity of overall symptoms: long‐term (6 to 10 days)… compared with placebo (high certainty).

1 finding from 1 review

Antihistamines vs placebo

Nausea · preventing nausea and vomiting

It is very uncertain whether antihistamines changes nausea ‐ intraoperative compared with placebo (very low certainty).

2 findings from 1 review

Sedating antihistamines vs placebo

Change in severity of overall symptoms: short‐term (1 to 2 days) Subjective severity score · patients with common cold

Sedating antihistamines leads to lower change in severity of overall symptoms: short‐term (1 to 2 days)… compared with placebo (high certainty).

1 finding from 1 review

Sedating antihistamines vs placebo

Change in severity of overall symptoms: long‐term (6 to 10 days) Subjective severity score · patients with common cold

Sedating antihistamines showed no clear difference in change in severity of overall symptoms: long‐term (6 to 10 days)… compared with placebo (high certainty).

1 finding from 1 review