Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,123 questions · 2,188 findings · 243 reviews

No studies found 493 · 22.5%GRADE not reported 160 · 7.3%Very low 600 · 27.4%Low 474 · 21.7%Moderate 364 · 16.6%High 97 · 4.4%

Summary of findings: Inhaled antibiotics vs IV antibiotics

Need for additional IV or oral antibiotics · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

It is very uncertain whether summary of findings: Inhaled antibiotics changes need for additional IV or oral antibiotics compared with IV antibiotics (very low certainty).

1 finding from 1 review

Antibiotic prophylaxis before dental procedure vs placebo or no prophylaxis

Adverse effects of antibiotics · Adults or children at increased risk of bacterial endocarditis (pre-existing cardiac condition) undergoing an invasive dental procedure

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotic prophylaxis before dental procedure vs placebo or no prophylaxis

Cost implications of antibiotic provision · Adults or children at increased risk of bacterial endocarditis (pre-existing cardiac condition) undergoing an invasive dental procedure

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Delayed antibiotics vs no antibiotics

Patient satisfaction: delayed (prescription collection) versus no antibiotics · respiratory infections

Summary of findings table ‐ Delayed antibiotics probably leads to higher patient satisfaction: delayed (prescription collection) versus no… compared with no antibiotics (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Delayed antibiotics vs immediate antibiotics

Antibiotic use: delayed (all strategies) versus immediate antibiotics · respiratory infections

Summary of findings table ‐ Delayed antibiotics probably leads to lower antibiotic use: delayed (all strategies) versus immediate antibiotics compared with immediate antibiotics (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Delayed antibiotics vs immediate antibiotics

Patient satisfaction: delayed (all strategies) versus immediate antibiotics · respiratory infections

Summary of findings table ‐ Delayed antibiotics showed no clear difference in patient satisfaction: delayed (all strategies) versus immediate… compared with immediate antibiotics (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Delayed antibiotics vs immediate antibiotics

Reconsultations · respiratory infections

Summary of findings table ‐ Delayed antibiotics showed no clear difference in reconsultation rate: delayed (all strategies) versus immediate… compared with immediate antibiotics (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Delayed antibiotics vs no antibiotics

Antibiotic use: delayed (all strategies) versus no antibiotics · respiratory infections

Summary of findings table ‐ Delayed antibiotics probably leads to higher antibiotic use: delayed (all strategies) versus no antibiotics compared with no antibiotics (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo compared

Adverse effects of antibiotics · children, aged 2 to 59 months, with WHO‐defined non‐severe pneumonia and wheeze

Antibiotic therapy showed no clear difference in treatment harms (adverse events or side effects associated with… compared with placebo compared to placebo (low certainty).

1 finding from 1 review