Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

33 questions · 36 findings · 4 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 7 · 19.4%Low 6 · 16.7%Moderate 17 · 47.2%High 6 · 16.7%

Angiotensin receptor blockers (ARBs) vs placebo or no treatment

Hyperkalaemia · patients with chronic heart failure with preserved ejection fraction

Angiotensin receptor blockers (ARBs) leads to higher hyperkalaemia compared with placebo or no treatment (high certainty).

1 finding from 1 review

Angiotensin receptor blockers (ARBs) vs placebo or no treatment

All‐cause mortality (RR) · patients with chronic heart failure with preserved ejection fraction

Angiotensin receptor blockers (ARBs) showed no clear difference in all‐cause mortality (RR) compared with placebo or no treatment (high certainty).

1 finding from 1 review

Angiotensin‐converting enzyme inhibitors vs ARB

Total mortality · people with primary hypertension

All angiotensin converting enzyme (ACE) inhibitors showed no clear difference in total mortality compared with all angiotensin receptor blockers (ARBs) (moderate certainty).

1 finding from 1 review

Angiotensin‐converting enzyme inhibitors vs ARB

Cardiovascular events · people with primary hypertension

All angiotensin converting enzyme (ACE) inhibitors showed no clear difference in total cardiovascular events compared with all angiotensin receptor blockers (ARBs) (low certainty).

1 finding from 1 review

Angiotensin‐converting enzyme inhibitors vs ARB

Withdrawals due to adverse events · people with primary hypertension

All angiotensin converting enzyme (ACE) inhibitors leads to lower withdrawal due to adverse effects compared with all angiotensin receptor blockers (ARBs) (high certainty).

1 finding from 1 review

CHRONIC: ACEi or ARB vs placebo

All‐cause mortality · Patients undergoing any type of surgery under general anaesthesia receiving ACEIs or ARBs perioperatively

It is very uncertain whether ACEIs or ARBs changes all‐cause mortality compared with placebo (very low certainty).

1 finding from 1 review

CHRONIC: ACEi or ARB vs placebo

Risk of acute myocardial ischaemia · Patients undergoing any type of surgery under general anaesthesia receiving ACEIs or ARBs perioperatively

It is very uncertain whether ACEIs or ARBs changes risk of acute myocardial ischaemia compared with placebo (very low certainty).

1 finding from 1 review

CHRONIC: ACEi or ARB vs placebo

Rate of perioperative cerebrovascular complications · Patients undergoing any type of surgery under general anaesthesia receiving ACEIs or ARBs perioperatively

It is very uncertain whether ACEIs or ARBs changes rate of perioperative cerebrovascular complications compared with placebo (very low certainty).

1 finding from 1 review