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Evidence found and GRADE certainty

4,771 questions · 10,185 findings · 893 reviews

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No studies found 2,109 · 20.7%GRADE not reported 1,125 · 11%Very low 2,279 · 22.4%Low 2,514 · 24.7%Moderate 1,709 · 16.8%High 449 · 4.4%

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Sulthiame vs phenytoin

Gingival hyperplasia · participants with epilepsy (GTCS)

Sulthiame may leads to lower gingival hyperplasia compared with phenytoin (low certainty).

1 finding from 1 review

Sulthiame vs phenytoin

Other · participants with epilepsy (GTCS)

Sulthiame showed no clear difference in other compared with phenytoin (low certainty).

1 finding from 1 review

Sulthiame vs levetiracetam

Treatment withdrawal · participants with epilepsy (BECTS)

Sulthiame showed no clear difference in treatment withdrawal compared with levetiracetam (low certainty).

1 finding from 1 review

Sulthiame vs levetiracetam

Seizure freedom · participants with epilepsy (BECTS)

Sulthiame showed no clear difference in seizure freedom compared with levetiracetam (low certainty).

1 finding from 1 review

Sulthiame vs levetiracetam

Adverse effects (general symptoms) · participants with epilepsy (BECTS)

Sulthiame showed no clear difference in adverse effects (general symptoms) compared with levetiracetam (low certainty).

1 finding from 1 review

Sulthiame vs levetiracetam

Adverse effects (central nervous system) · participants with epilepsy (BECTS)

Sulthiame showed no clear difference in adverse effects (central nervous system) compared with levetiracetam (low certainty).

1 finding from 1 review

Sulthiame vs levetiracetam

Adverse effects (behaviour) · participants with epilepsy (BECTS)

Sulthiame showed no clear difference in adverse effects (behaviour) compared with levetiracetam (low certainty).

1 finding from 1 review

Sulthiame vs levetiracetam

Adverse effects (airways) · participants with epilepsy (BECTS)

Sulthiame may leads to higher adverse effects (airways) compared with levetiracetam (low certainty).

1 finding from 1 review

Autologous blood or PRP vs placebo at 3 months' follow‐up

Treatment success (> 25% improvement in pain or function) · lateral elbow pain

It is very uncertain whether autologous blood or PRP changes treatment success (> 25% improvement in pain or function) compared with placebo at 3 months' follow‐up (very low certainty).

1 finding from 1 review

Autologous blood or PRP vs placebo at 3 months' follow‐up

Adverse events (pain and swelling at injection site and limitation of elbow movement following injection) · lateral elbow pain

Autologous blood or PRP showed no clear difference in adverse events (pain and swelling at injection site and limitation… compared with placebo at 3 months' follow‐up (low certainty).

1 finding from 1 review

Surfactant administration via thin catheter (S‐TC) vs surfactant administration through an endotracheal tube (S‐ETT)

Death or bronchopulmonary dysplasia at 36 weeks PMA · preterm infants with or at risk of respiratory distress syndrome

Surfactant administration via thin catheter (S‐TC) probably leads to lower death or bronchopulmonary dysplasia (BPD) at 36 weeks' postmenstrual… compared with surfactant administration through an endotracheal tube (S‐ETT) (moderate certainty).

1 finding from 1 review

Surfactant administration via thin catheter (S‐TC) vs surfactant administration through an endotracheal tube (S‐ETT)

Need for intubation within the first 72 hours · preterm infants with or at risk of respiratory distress syndrome

Surfactant administration via thin catheter (S‐TC) probably leads to lower need for intubation within the first 72 hours compared with surfactant administration through an endotracheal tube (S‐ETT) (moderate certainty).

1 finding from 1 review

Surfactant administration via thin catheter (S‐TC) vs surfactant administration through an endotracheal tube (S‐ETT)

Air leak requiring drainage · preterm infants with or at risk of respiratory distress syndrome

Surfactant administration via thin catheter (S‐TC) showed no clear difference in air leak requiring drainage compared with surfactant administration through an endotracheal tube (S‐ETT) (low certainty).

1 finding from 1 review

Surfactant administration via thin catheter (S‐TC) vs surfactant administration through an endotracheal tube (S‐ETT)

Severe intraventricular haemorrhage · preterm infants with or at risk of respiratory distress syndrome

Surfactant administration via thin catheter (S‐TC) may leads to lower severe intraventricular haemorrhage (grade III or IV) compared with surfactant administration through an endotracheal tube (S‐ETT) (low certainty).

1 finding from 1 review