Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

929 questions · 946 findings · 295 reviews · Headline outcomes only

No studies found 150 · 15.9%GRADE not reported 47 · 5%Very low 312 · 33%Low 262 · 27.7%Moderate 138 · 14.6%High 37 · 3.9%

Auto‐CPAP vs fixed CPAP

Number of participants using machine for 4 or more hours per night · adults with a diagnosis of OSA

Auto‐CPAP showed no clear difference in number of participants using machine for 4 or more hours per night compared with fixed CPAP (low certainty).

1 finding from 1 review

Exercise vs NSAIDs

Use of rescue medication · young women with suspected primary dysmenorrhoea

It is very uncertain whether exercise changes use of rescue analgesic medication assessed by: number of women who… compared with non‐steroidal anti‐inflammatory drugs (NSAIDs) (very low certainty).

1 finding from 1 review

Summary of findings: bevacizumab vs ranibizumab

BCVA: gain of 15 or more ETDRS letters · people with neovascular age‐related macular degeneration

Summary of findings: bevacizumab showed no clear difference in gain of 15 or more letters visual acuity at 1 year compared with ranibizumab (high certainty).

1 finding from 1 review

Intervention not reported

Infusion‐related reactions (number of participants with one or more reaction) · adults and children with mucopolysaccharidosis I

The intervention showed no clear difference in infusion‐related reactions (number of participants with one or more… (low certainty).

1 finding from 1 review

Surgery with excision of failed tape vs surgery without excision of tape

Objective cure rates in the longer‐term ‐ more than 12 months, · women with recurrent stress urinary incontinence after failed minimally invasive midurethral tape surgery

The review found no eligible studies for this question.

1 finding from 1 review

Repeat midurethral tape (any type) vs any other non‐tape surgical treatment (e.g. traditional sling, colposuspension, injectables)

Objective cure rates in the longer‐term ‐ more than 12 months, · women with recurrent stress urinary incontinence after failed minimally invasive midurethral tape surgery

The review found no eligible studies for this question.

1 finding from 1 review

One type of repeat midurethral tape vs another type of repeat midurethral tape

Objective cure rates in the longer‐term ‐ more than 12 months, · women with recurrent stress urinary incontinence after failed minimally invasive midurethral tape surgery

The review found no eligible studies for this question.

1 finding from 1 review

Sulthiame add‐on vs placebo

Number experiencing adverse effects · patients between 3 to 15 months of age with West syndrome

It is very uncertain whether sulthiame add‐on changes adverse effects: total number of participants experiencing one or… compared with placebo (very low certainty).

1 finding from 1 review