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Evidence found and GRADE certainty

662 questions · 720 findings · 164 reviews

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No studies found 177 · 24.6%GRADE not reported 126 · 17.5%Very low 144 · 20%Low 139 · 19.3%Moderate 107 · 14.9%High 27 · 3.8%

Summary of findings: needle acupuncture plus valproate vs valproate

Frequency of adverse effects ‐ malaise ( · participants with generalised epilepsy

Summary of findings: needle acupuncture plus valproate showed no clear difference in frequency of adverse effects ‐ malaise ( compared with valproate alone (low certainty).

1 finding from 1 review

Summary of findings: needle acupuncture plus valproate vs valproate

Frequency of adverse effects ‐ sleepiness ( · participants with generalised epilepsy

Summary of findings: needle acupuncture plus valproate showed no clear difference in frequency of adverse effects ‐ sleepiness ( compared with valproate alone (low certainty).

1 finding from 1 review

Imiquimod 5% cream with tazarotene 0.1% gel vs Imiquimod 5% cream alone

Discontinuation of treatment due to side effects ( · participants with melanoma in situ, including lentigo maligna

Imiquimod 5% cream with tazarotene 0.1% gel showed no clear difference in secondary outcome: Discontinuation of treatment because of harms… compared with imiquimod 5% cream alone (low certainty).

1 finding from 1 review

Transbuccal miniplate combined with intraoral approach vs Intraoral approach alone

Post-operative infection (persistent) · Adults with fractures of the mandibular angle

Transbuccal miniplate combined with intraoral approach showed no clear difference in post-operative infection (persistent) compared with intraoral approach alone; GRADE not reported.

1 finding from 1 review

Summary of findings: multimedia education and a co‐intervention vs co‐intervention alone

Medication side effects Mean adverse self‐medication behaviour score (lower scores indicate safer self‐medication behaviour). Scale from: 0 to 40. · patients taking prescribed and over‐the‐counter medications or their carers
1 finding from 1 review

Nutritional supplement (500ml) and standard diet vs standard diet

Mild acute rejection episodes (within 6 months after LTx) · adult patients before and after liver transplantation.

It is very uncertain whether nutritional supplement (500ml) and standard diet changes mild acute rejection episodes (within 6 months after LTx) compared with standard diet alone (very low certainty).

1 finding from 1 review

Nutritional supplement (500ml) and standard diet vs standard diet

Severe acute rejection episodes (within six months after LTx) · adult patients before and after liver transplantation.

It is very uncertain whether nutritional supplement (500ml) and standard diet changes severe acute rejection episodes (within six months after LTx) compared with standard diet alone (very low certainty).

1 finding from 1 review

Anti‐leukaemic therapy plus alemtuzumab vs anti‐leukaemic therapy alone (anti‐leukaemic therapy identical

Infections (all grades) · people with chronic lymphocytic leukaemia

Anti‐leukaemic therapy plus alemtuzumab may leads to higher infections (all grades) compared with anti‐leukaemic therapy alone (anti‐leukaemic therapy identical (low certainty).

1 finding from 1 review

Cytarabine plus high‐dose methotrexate vs high‐dose methotrexate alone

Severe adverse effects (grade 3+): Infection · patients with primary CNS lymphoma

Cytarabine plus high‐dose methotrexate probably leads to higher infections (grade 3 to 4) compared with high‐dose methotrexate alone (moderate certainty).

1 finding from 1 review

Flossing plus toothbrushing (self-performed; manual or automated floss) vs Toothbrushing alone

Side effects · Dentate adults aged 16 years or older (excluding orthodontic patients and those with severe periodontal disease)
1 finding from 1 review

Traditional iliac bone graft plus fibrin glue vs Traditional iliac bone graft alone

Wound infection · Patients aged 7 to 16 years with unilateral or bilateral cleft lip and palate (alveolar cleft)

Traditional iliac bone graft plus fibrin glue showed no clear difference in postoperative complication: wound infection compared with traditional iliac bone graft alone; GRADE not reported.

1 finding from 1 review

Any Psychosocial plus any Pharmacological vs any Pharmachological alone compared to

Dropout · patients with opioid detoxification

Any Psychosocial plus any Pharmacological probably leads to lower dropouts ‐ All studies objective compared with any Pharmachological alone compared to (moderate certainty).

1 finding from 1 review

Any Psychosocial plus any Pharmacological vs any Pharmachological alone compared to

use of opiate during treatment ( · patients with opioid detoxification

Any Psychosocial plus any Pharmacological probably leads to lower use of opiate during the treatment objective compared with any Pharmachological alone compared to (moderate certainty).

1 finding from 1 review

Any Psychosocial plus any Pharmacological vs any Pharmachological alone compared to

Compliance as clinical absences during the tratment objective · patients with opioid detoxification

Any Psychosocial plus any Pharmacological probably leads to lower compliance as clinical absences during the tratment objective compared with any Pharmachological alone compared to (moderate certainty).

1 finding from 1 review

Occlusal adjustment as an adjunct to surgical periodontal therapy vs Surgical periodontal therapy alone (no occlusal adjustment)

Adverse effects (e.g. thermal sensitivity, over-eruption, TMJ symptoms, poor aesthetics, reduced oral hygiene) · Adults with chronic periodontitis

The review found no eligible studies for this question.

1 finding from 1 review