Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

407 questions · 500 findings · 40 reviews

No studies found 115 · 23%GRADE not reported 185 · 37%Very low 89 · 17.8%Low 63 · 12.6%Moderate 36 · 7.2%High 12 · 2.4%

Topical disinfectants vs standard care or other active treatment (antibiotic or other disinfectant)

Peritonitis · chronic peritoneal dialysis patients

Topical disinfectants showed no clear difference in peritonitis (number of patients with one or more episodes) compared with standard care or other active treatment (antibiotic or other… (low certainty).

1 finding from 1 review

Topical disinfectants vs standard care or other active treatment (antibiotic or other disinfectant)

Exit‐site/tunnel infection · chronic peritoneal dialysis patients

Topical disinfectants showed no clear difference in exit‐site/tunnel infection (number of patients with one or more… compared with standard care or other active treatment (antibiotic or other… (low certainty).

1 finding from 1 review

Topical disinfectants vs standard care or other active treatment (antibiotic or other disinfectant)

Catheter removal or replacement · chronic peritoneal dialysis patients

Topical disinfectants showed no clear difference in catheter removal or replacement (number of patients) compared with standard care or other active treatment (antibiotic or other… (low certainty).

1 finding from 1 review

Chlorhexidine dressing following alcohol cleansing vs polyurethane dressing following aqueous povidone‐iodine cleansing

Sepsis without a source · newborn infants with central venous catheters

Chlorhexidine dressing following alcohol cleansing showed no clear difference in sepsis without a source compared with polyurethane dressing following aqueous povidone‐iodine cleansing (moderate certainty).

1 finding from 1 review

Chlorhexidine dressing following alcohol cleansing vs polyurethane dressing following aqueous povidone‐iodine cleansing

Catheter‐related blood stream infection · newborn infants with central venous catheters

Chlorhexidine dressing following alcohol cleansing showed no clear difference in catheter‐related blood stream infection compared with polyurethane dressing following aqueous povidone‐iodine cleansing (moderate certainty).

1 finding from 1 review

Chlorhexidine dressing following alcohol cleansing vs polyurethane dressing following aqueous povidone‐iodine cleansing

Catheter colonisation · newborn infants with central venous catheters

Chlorhexidine dressing following alcohol cleansing probably leads to lower catheter colonisation compared with polyurethane dressing following aqueous povidone‐iodine cleansing (moderate certainty).

1 finding from 1 review

Chlorhexidine dressing following alcohol cleansing vs polyurethane dressing following aqueous povidone‐iodine cleansing

Adverse effects: contact dermatitis · newborn infants with central venous catheters

Chlorhexidine dressing following alcohol cleansing probably leads to higher adverse effects: contact dermatitis compared with polyurethane dressing following aqueous povidone‐iodine cleansing (moderate certainty).

1 finding from 1 review

Silver‐alginate dressing vs control

CRBSI ‐ Unit of analysis: infants Clinical and microbiological methods · newborn infants with central venous catheters

Silver‐alginate dressing showed no clear difference in CRBSI ‐ Unit of analysis: infants Clinical and microbiological methods compared with control (moderate certainty).

1 finding from 1 review

Silver‐alginate dressing vs control

CRBSI ‐ Unit of analysis: catheters Clinial and microbiological methods · newborn infants with central venous catheters

Silver‐alginate dressing showed no clear difference in CRBSI ‐ Unit of analysis: catheters Clinial and microbiological… compared with control (moderate certainty).

1 finding from 1 review

Combined oral and intravenous vs oral or intravenous alone

Wound infection · colorectal surgery

Combined oral and intravenous leads to lower surgical wound infection: oral + iv versus iv alone compared with oral or intravenous alone (high certainty).

2 findings from 1 review

Azithromycin vs erythromycin

Bacteriological failure · Adults and children with cholera diarrhoea

Azithromycin showed no clear difference in bacteriological failure compared with erythromycin (low certainty).

1 finding from 1 review

Tetracycline vs doxycycline

Bacteriological failure · Adults and children with cholera diarrhoea

Tetracycline probably leads to lower bacteriological failure compared with doxycycline (moderate certainty).

1 finding from 1 review