Cochrane · systematic review · CD008625
Antimicrobial drugs for treating cholera
Leibovici‐Weissman, Y, Neuberger, A, Bitterman, R, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
Infectious DiseasesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
23
current version
GRADE rated
22
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 4.3%Very low 0 · 0%Low 11 · 47.8%Moderate 11 · 47.8%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antimicrobial drugs versus placebo/no treatment for treating cholera
Population: Adults and children with cholera diarrhoea
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Diarrhoea duration Antimicrobial drugs vs placebo/no treatment | no estimate extracted | 19 studies · 1013 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Stool volume Antimicrobial drugs vs placebo/no treatment | no estimate extracted | 18 studies · 1042 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Hydration fluid requirements Antimicrobial drugs vs placebo/no treatment | no estimate extracted | 11 studies · 1201 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Duration of pathogen secretion Antimicrobial drugs vs placebo/no treatment | no estimate extracted | 12 studies · 740 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Deaths Antimicrobial drugs vs placebo/no treatment | no estimate extracted | 7 studies · 299 participants | Ungraded |
Azithromycin versus ciprofloxacin for treating cholera
Population: Adults and children with cholera diarrhoea
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Diarrhoea duration Azithromycin vs ciprofloxacin | no estimate extracted | 2 studies · 375 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Stool volume Azithromycin vs ciprofloxacin | no estimate extracted | 1 study · 195 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Bacteriological failure Azithromycin vs ciprofloxacin | RR 0.23 [0.16, 0.34] | 2 studies · 375 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Azithromycin versus erythromycin for treating cholera
Population: Adults and children with cholera diarrhoea
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Diarrhoea duration Azithromycin vs erythromycin | no estimate extracted | 2 studies · 179 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Stool volume Azithromycin vs erythromycin | no estimate extracted | 2 studies · 172 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Bacteriological failure Azithromycin vs erythromycin | RR 1.56 [0.8, 3.02] | 2 studies · 179 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Tetracycline versus doxycycline for treating cholera
Population: Adults and children with cholera diarrhoea
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Diarrhoea duration Tetracycline vs doxycycline | no estimate extracted | 3 studies · 230 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Stool volume Tetracycline vs doxycycline | no estimate extracted | 3 studies · 336 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Bacteriological failure Tetracycline vs doxycycline | RR 0.2 [0.06, 0.68] | 2 studies · 198 participants | Moderate Downgraded: risk of bias, imprecision |
Tetracycline versus quinolones for treating cholera
Population: Adults and children with cholera diarrhoea
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Diarrhoea duration Tetracycline vs quinolones | no estimate extracted | 3 studies · 259 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Stool volume Tetracycline vs quinolones | no estimate extracted | 2 studies · 236 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Bacteriological failure Tetracycline vs quinolones | RR 0.99 [0.14, 6.82] | 2 studies · 234 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Doxycycline versus quinolones for treating cholera
Population: Adults and children with cholera diarrhoea
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Diarrhoea duration Doxycycline vs quinolones | no estimate extracted | 3 studies · 126 participants | Low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Stool volume Doxycycline vs quinolones | no estimate extracted | 4 studies · 435 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Bacteriological failure Doxycycline vs quinolones | RR 5.84 [2.7, 12.65] | 4 studies · 386 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Short compared to long duration of antimicrobials for treating cholera
Population: Adults and children with cholera diarrhoea
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Diarrhoea duration Short vs long duration of antimicrobials | MD 0.34 | 7 studies · 431 participants | Low Downgraded: risk of bias, inconsistency |
Stool Volume Short vs long duration of antimicrobials | no estimate extracted | 8 studies · 496 participants | Low Downgraded: risk of bias, inconsistency |
Bacteriological failure Short vs long duration of antimicrobials | RR 1.53 [1.01, 2.32] | 9 studies · 672 participants | Low Downgraded: risk of bias, imprecision |