Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,534 questions · 5,247 findings · 456 reviews

No studies found 1,142 · 21.8%GRADE not reported 1,503 · 28.6%Very low 1,040 · 19.8%Low 869 · 16.6%Moderate 554 · 10.6%High 139 · 2.6%

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Longer self‐certification vs shorter self‐certification

CBA: Average lost work time per 100 person‐years · workers
2 findings from 1 review

Vi‐rEPA vaccine (2 doses) vs control

Cumulative cases of typhoid fever at 2 years · adults and children of 2 years of age and older

Vi‐rEPA vaccine (2 doses) probably leads to lower cumulative cases of typhoid fever at 2 years compared with control (moderate certainty).

2 findings from 1 review

Ty21a vaccine (three doses) vs control

Cumulative cases of typhoid fever at 2.5 to 3 years · adults and children aged 5 years of age and older

Ty21a vaccine (three doses) probably leads to lower cumulative cases of typhoid fever at 2.5 to 3 years compared with control (moderate certainty).

1 finding from 1 review

Vi polysaccharide vaccine (1 dose) vs control

Cumulative cases of typhoid fever at 2.5 to 3 years · adults and children of 2 years of age and older

Vi polysaccharide vaccine (1 dose) may leads to lower cumulative cases of typhoid fever at 2.5 to 3 years compared with control (low certainty).

1 finding from 1 review

Medication reconciliation interventions vs usual care

Hospital usage (composite measure of ED, rehospitalisation) · all patients (aged > 18 years) at a transition of care

It is very uncertain whether medication reconciliation interventions changes hospital usage (composite measure of ED, rehospitalisation) compared with standard care (very low certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events Measured by: proportion of serious adverse events (total) Average study duration (range): not stated · children and adolescents aged 18 years and under diagnosed with ADHD

It is very uncertain whether the intervention changes serious adverse events Measured by: proportion of serious adverse… (very low certainty).

1 finding from 1 review

Intervention not reported

Withdrawal of methylphenidate due to serious adverse events (non‐comparative cohort studies) Measured by: proportion of participants withdrawn from treatment Average study duration (range): 7.9 months (1 month to 37 months) · children and adolescents aged 18 years and under diagnosed with ADHD
1 finding from 1 review

Intervention not reported

Withdrawal of methylphenidate due to adverse events of unknown severity Measured by: proportion of participants withdrawn from treatment Average study duration (range): 4.6 months (21 days to 36 months) · children and adolescents aged 18 years and under diagnosed with ADHD
1 finding from 1 review

Intervention not reported

Withdrawal of methylphenidate due to non‐serious adverse events Measured by: proportion of participants withdrawn from treatment Average study duration (range): 5.60 months (0.6 months to 41 months) · children and adolescents aged 18 years and under diagnosed with ADHD
1 finding from 1 review

Intervention not reported

Withdrawal of methylphenidate for unknown reasons Measure by: proportion of participants withdrawn from treatment Average study duration (range): 6.13 months (1 day to 36 months) · children and adolescents aged 18 years and under diagnosed with ADHD
1 finding from 1 review