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Evidence found and GRADE certainty

4,411 questions · 5,986 findings · 226 reviews · Oral Health

No studies found 1,305 · 21.8%GRADE not reported 2,988 · 49.9%Very low 1,030 · 17.2%Low 476 · 8%Moderate 156 · 2.6%High 31 · 0.5%

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Cyclosporin A in orabase (topical) vs Placebo (orabase)

Oral ulcers (number, size, healing time) · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • Ergun 1997 (cyclosporin A in orabase vs placebo orabase, 24 patients; high risk of reporting bias): no data were presented; authors reported no clinical improvement in the number, size, and healing time of ulcers for…
    1 study · 24 participants
    GRADE not reported

NobelActive internal connection implants vs NobelReplace implants

Implant failure · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year

NobelActive internal connection implants showed no clear difference in implant failure compared with nobelReplace implants; GRADE not reported.

1 finding from 1 review

One-stage augmentation (implants placed simultaneously) vs Two-stage augmentation (delayed implant placement)

Prosthesis failure · Patients with insufficient bone below the maxillary sinus requiring dental implants

One-stage augmentation (implants placed simultaneously) showed no clear difference in prosthesis failure compared with two-stage augmentation (delayed implant placement); GRADE not reported.

1 finding from 1 review

Astra cylindrical turned surface implants vs Astra cylindrical TiO2-blasted surface implants

Implant failure · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year
1 finding from 1 review

Surgical anchorage (mini-screw or mid-palatal implant) vs Conventional anchorage (headgear, transpalatal/palatal arch, etc.)

Patient perception: pain · Patients of any age undergoing orthodontic treatment with fixed appliances and requiring anchorage (adolescents to adults up to 48-54 years)
1 finding from 1 review

Depot corticosteroids (systemic; 40 mg methylprednisolone IM every 3 weeks for 27 weeks) vs placebo injection

Mean number of oral ulcers · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care

Depot corticosteroids (systemic; 40 mg methylprednisolone IM every 3… showed no clear difference in mean number of oral ulcers compared with placebo (saline IM injection); GRADE not reported.

1 finding from 1 review

Pre-drilling mini-screw implant vs Self-drilling mini-screw implant

Patient perception: pain · Patients undergoing orthodontic treatment requiring surgical (mini-screw implant) anchorage
1 finding from 1 review

Interferon-alpha (systemic) vs Placebo (subcutaneous)

Safety of the intervention (adverse effects) · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • Alpsoy 2002: high rate of adverse events including alopecia, leukopenia, and diarrhoea; 18 of 23 patients in the treatment arm experienced mild flu-like symptoms.
    1 study · 50 participants
    GRADE not reported

Powered toothbrush, circular action vs Manual toothbrush

Gingivitis · Individuals of any age with no reported disability that might affect toothbrushing (including people wearing orthodontic appliances)

Powered toothbrush, circular action showed no clear difference in gingivitis score (1 to 3 months) compared with manual toothbrush; GRADE not reported.

1 finding from 1 review

Cyclosporin (systemic; 10 mg/kg/day for 16 weeks) vs Colchicine (systemic; 1 mg daily)

Alleviation of oral aphthous ulcers · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care

Cyclosporin (systemic; 10 mg/kg/day for 16 weeks) led to higher alleviation of oral aphthous ulcers compared with colchicine (systemic; 1 mg daily); GRADE not reported.

1 finding from 1 review

WINSIX cylindrical implants vs WINSIX tapered implants

Implant failure · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year

WINSIX cylindrical implants showed no clear difference in implant failure compared with WINSIX tapered implants; GRADE not reported.

1 finding from 1 review

Primary outcome: topical local anaesthetics vs placebo or no treatment

Participant satisfaction · Children and young people aged 17 years or younger having dental treatment (including extractions) under general anaesthesia (secondary…

The review found no eligible studies for this question.

1 finding from 1 review

Repair of a defective resin composite restoration in a permanent molar or premolar tooth (with resin composite) vs Replacement of a defective resin composite restoration in a permanent molar or premolar tooth (with resin composite)

Perioperative or postoperative pain or discomfort · Adults (16 years or over) with one or more defective resin composite restoration(s) in a molar or premolar tooth/teeth

The review found no eligible studies for this question.

1 finding from 1 review

Bio-Oss (anorganic bovine bone) vs A different bone substitute

Complication at augmented site · Patients undergoing two-stage maxillary sinus augmentation

Bone substitute (anorganic bovine bone / Bio-Oss) showed no clear difference in complications at augmented site compared with A different bone substitute; GRADE not reported.

1 finding from 1 review

Removable appliance with palatal crib associated with high-pull chincup vs no treatment

Position of the incisors (upper incisor inclination) · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
1 finding from 1 review
  • Orthodontic and orthopaedic treatment for anterior open bite in children 2014 · Cochrane All outcomes
    End of treatment (12 months)
    The author reported that data (1.NA, 1-NA, 1-PP, 1.NB, 1-NB, 1-GoMe) showed a statistically significant difference. There was palatal inclination of the upper incisors in the intervention group that contributed to…
    1 study
    GRADE not reported

Repair of a defective resin composite restoration in a permanent molar or premolar tooth (with resin composite) vs Replacement of a defective resin composite restoration in a permanent molar or premolar tooth (with resin composite)

Extraction of tooth (due to decay) · Adults (16 years or over) with one or more defective resin composite restoration(s) in a molar or premolar tooth/teeth

The review found no eligible studies for this question.

1 finding from 1 review

One-stage augmentation (implants placed simultaneously) vs Two-stage augmentation (delayed implant placement)

Complications · Patients with insufficient bone below the maxillary sinus requiring dental implants

One-stage augmentation (implants placed simultaneously) showed no clear difference in complications compared with two-stage augmentation (delayed implant placement); GRADE not reported.

1 finding from 1 review