Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

949 questions · 1,008 findings · 130 reviews · Gynaecology and Fertility

No studies found 195 · 19.3%GRADE not reported 30 · 3%Very low 346 · 34.3%Low 323 · 32%Moderate 101 · 10%High 13 · 1.3%

Pharmacological interventions vs pharmacological intervention

Clinical pregnancyMetformin plus liraglutide vs metformin Met + CC + L‐carnitine vs Met + CC + placebo · obese women with subfertility

It is very uncertain whether pharmacological intervention changes clinical pregnancyMetformin plus liraglutide vs metformin Met + CC +… compared with pharmacological intervention (very low certainty).

1 finding from 1 review

LOD with and without medical ovulation vs medical ovulation induction alone

Multiple pregnancy · women with anovulatory PCOS and CC resistance

LOD with and without medical ovulation probably leads to lower multiple pregnancy compared with medical ovulation induction alone (moderate certainty).

1 finding from 1 review

LOD with and without medical ovulation vs medical ovulation induction alone

Clincial pregnancy · women with anovulatory PCOS and CC resistance

LOD with and without medical ovulation showed no clear difference in clincial pregnancy compared with medical ovulation induction alone (low certainty).

1 finding from 1 review

IUI in a stimulated cycle vs TI or expectant management

Ectopic pregnancy rate per couple · participants with unexplained subfertility

IUI in a stimulated cycle showed no clear difference in ectopic pregnancy rate per couple compared with TI or expectant management (low certainty).

2 findings from 1 review

IUI in a stimulated cycle vs TI or expectant management

Multiple pregnancy rate · participants with unexplained subfertility

IUI in a stimulated cycle showed no clear difference in multiple pregnancy rate per couple compared with TI or expectant management (low certainty).

2 findings from 1 review

IUI in a natural cycle vs TI or expectant management

Multiple pregnancy rate · participants with unexplained subfertility

IUI in a natural cycle showed no clear difference in multiple pregnancy rate per couple compared with TI or expectant management (low certainty).

2 findings from 1 review