Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

954 questions · 963 findings · 130 reviews · Headline outcomes only

No studies found 181 · 18.8%GRADE not reported 71 · 7.4%Very low 163 · 16.9%Low 311 · 32.3%Moderate 163 · 16.9%High 74 · 7.7%

Insulin Detemir + prandial insulin Aspart vs NPH insulin + prandial insulin Aspart (Different insulin types within similar insulin regimens)

Fetal anomaly (major) · pregnant women with pre‐existing diabetes

It is very uncertain whether insulin Detemir + prandial insulin Aspart changes fetal anomaly (major) compared with NPH insulin + prandial insulin Aspart (Different insulin types… (very low certainty).

1 finding from 1 review

Lispro vs regular insulin (Different insulin types within similar insulin regimens)

Fetal anomaly · pregnant women with pre‐existing diabetes

It is very uncertain whether lispro changes fetal anomaly compared with regular insulin (Different insulin types within similar insulin… (very low certainty).

1 finding from 1 review

Lifestyle vs control ‐ Neonatal and later outcomes

Perinatal (fetal and neonatal death) and later infant mortality · women with gestational diabetes mellitus

Lifestyle showed no clear difference in perinatal (fetal and neonatal death) and later infant mortality compared with control ‐ Neonatal and later outcomes (low certainty).

1 finding from 1 review

Insulin vs anti‐diabetic agent

Perinatal (fetal and neonatal death) and later infant mortality · Infants of women diagnosed with gestational diabetes

Insulin showed no clear difference in perinatal (fetal and neonatal death) and later infant mortality compared with anti‐diabetic agent (low certainty).

1 finding from 1 review

Multivitamin plus iron plus folate vs iron plus folate

Total fetal loss (including miscarriages or combined miscarriages and stillbirths) · pregnant women

Multivitamin plus iron plus folate showed no clear difference in total fetal loss (including miscarriages or combined miscarriages… compared with iron plus folate (high certainty).

1 finding from 1 review

Pyridoxine vs placebo

Severity, reduction or cessation in nausea/vomiting 2. Quality of life outcomes 3. Pregnancy complications 4. Adverse fetal/neonatal outcomes · Pregnant women with hyperemesis gravidarum

The review found no eligible studies for this question.

1 finding from 1 review

Metoclopramide vs ondansetron

Severity, reduction or cessation in nausea/vomiting 2.Days of hospital admission 3. Pregnancy complications 4. Adverse fetal/neonatal outcomes · Pregnant women with hyperemesis gravidarum

The review found no eligible studies for this question.

1 finding from 1 review

Metoclopramide vs promethazine

Severity, reduction or cessation in nausea/vomiting 2. Number of episodes of emesis 3. Days of hospital admission 4. Pregnancy complications 5. Adverse fetal/neonatal outcomes · Pregnant women with hyperemesis gravidarum

The review found no eligible studies for this question.

1 finding from 1 review