Exacerbations needing hospitalisation · Studies recruited adults and adolescents aged 12 and older with chronic asthma
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Exacerbations requiring oral corticosteroids ‐ adults · Studies recruited adults and adolescents aged 12 and older with chronic asthma
SiT for maintenance/relief leads to lower patients with exacerbations requiring oral steroids compared with higher‐dose ICS/LABA + SABA (high certainty).
1 finding from 1 review
OR 0.75 [0.65, 0.87]
9096 participants
High
Patients with serious adverse events · Studies recruited adults and adolescents aged 12 and older with chronic asthma
SiT for maintenance/relief showed no clear difference in patients with serious adverse events compared with higher‐dose ICS/LABA + SABA (moderate certainty).
1 finding from 1 review
OR 0.92 [0.74, 1.13]
9130 participants
Moderate
Patients with severe exacerbations (requiring hospitalisation or ER visit) · Studies recruited adults and adolescents aged 12 and older with chronic asthma
SiT for maintenance/relief leads to lower patients with severe exacerbations (requiring hospitalisation or ER… compared with higher‐dose ICS/LABA + SABA (high certainty).
1 finding from 1 review
OR 0.72 [0.57, 0.9]
7768 participants
High
All‐cause mortality · patients with initial treatment of HIV infection in antiretroviral‐naive individuals
It is very uncertain whether d4T changes mortality compared with AZT (very low certainty).
1 finding from 1 review
Clinical progression · patients with initial treatment of HIV infection in antiretroviral‐naive individuals
d4T showed no clear difference in clinical progression compared with AZT (low certainty).
1 finding from 1 review
Severe adverse events · patients with initial treatment of HIV infection in antiretroviral‐naive individuals
d4T showed no clear difference in severe adverse events compared with AZT (low certainty).
1 finding from 1 review
Virologic response · patients with initial treatment of HIV infection in antiretroviral‐naive individuals
d4T showed no clear difference in virologic response compared with AZT (low certainty).
1 finding from 1 review
Adherence/tolerability/retention · patients with initial treatment of HIV infection in antiretroviral‐naive individuals
d4T showed no clear difference in adherence/tolerability/retention compared with AZT (low certainty).
1 finding from 1 review
Immunologic response · patients with initial treatment of HIV infection in antiretroviral‐naive individuals
1 finding from 1 review
Drug resistance · patients with initial treatment of HIV infection in antiretroviral‐naive individuals
It is very uncertain whether d4T changes drug resistance compared with AZT (very low certainty).
1 finding from 1 review
Serious adverse events · patients with initial ART
TDF showed no clear difference in serious adverse events compared with AZT (high certainty).
1 finding from 1 review
Virologic response · patients with initial ART
TDF showed no clear difference in virologic response compared with AZT (high certainty).
1 finding from 1 review
Adherence/tolerability/retention · patients with initial ART
TDF probably leads to higher adherence/tolerability/retention compared with AZT (moderate certainty).
1 finding from 1 review
Immunological response · patients with initial ART
1 finding from 1 review
Drug resistance · patients with initial ART
It is very uncertain whether TDF changes drug resistance compared with AZT (very low certainty).
1 finding from 1 review