Question · asked by 1 review
TDF vs AZT: Drug resistance
- Population
- patients with initial ART
- Intervention
- TDF
- Comparison
- AZT
- Outcome
- Drug resistance
It is very uncertain whether TDF changes drug resistance compared with AZT (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
TDF vs AZT Drug resistance · patients with initial ART It is very uncertain whether TDF changes drug resistance compared with AZT (very low certainty). Tenofovir or zidovudine in three‐drug combination therapy with one nucleoside reverse transcriptase… (2010) · Cochrane Headline outcomes only | RR 20.43 [1.24, 335.9] | 1 study · 71 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Tenofovir or zidovudine in three‐drug combination therapy with one nucleoside reverse transcriptase inhibitor and one non‐nucleoside… 2010 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.