Question · asked by 1 review
TDF vs AZT: Serious adverse events
- Population
- patients with initial ART
- Intervention
- TDF
- Comparison
- AZT
- Outcome
- Serious adverse events
TDF showed no clear difference in serious adverse events compared with AZT (high certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
TDF vs AZT Serious adverse events · patients with initial ART TDF showed no clear difference in serious adverse events compared with AZT (high certainty). Tenofovir or zidovudine in three‐drug combination therapy with one nucleoside reverse transcriptase… (2010) · Cochrane Headline outcomes only | RR 0.92 [0.6, 1.43] | 2 studies · 586 participants | High |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Tenofovir or zidovudine in three‐drug combination therapy with one nucleoside reverse transcriptase inhibitor and one non‐nucleoside… 2010 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
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How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.