Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,103 questions · 1,157 findings · 177 reviews · Headline outcomes only

No studies found 291 · 25.2%GRADE not reported 85 · 7.3%Very low 317 · 27.4%Low 258 · 22.3%Moderate 169 · 14.6%High 37 · 3.2%

Non‐platinum single‐agent vs non‐platinum combination treatment

Grade 3 to 4 neutropenia · non‐small cell lung cancer in the elderly population

Non‐platinum single‐agent may leads to higher grade 3 and 4 hematological adverse events (AE) ‐ neutropenia compared with non‐platinum combination treatment (low certainty).

1 finding from 1 review

Non‐platinum single‐agent vs non‐platinum combination treatment

Safety (AE, adverse drug reaction): thrombocytopenia Grades 3 or 4 according to National Cancer Institute · non‐small cell lung cancer in the elderly population

It is very uncertain whether non‐platinum single‐agent changes grade 3 and 4 hematological adverse events (AE) ‐ thrombocytopenia compared with non‐platinum combination treatment (very low certainty).

1 finding from 1 review

Rapid COJEC vs standard induction therapies

Early toxicities (during preoperative chemotherapy): febrile neutropenia (2 or more episodes), proven fungal infections, septicemia (1 or more episodes), gastrointestinal toxicity (grade 3 or 4), renal toxicity (glomerular filtration rate < 80 ml/... · patients with high‐risk neuroblastoma
1 finding from 1 review

Intervention not reported

The proportion of patients with lymphopenia at two years · Patients with relapsing‐remitting multiple sclerosis

The intervention probably leads to higher the proportion of patients with lymphopenia at two years (moderate certainty).

1 finding from 1 review

Maintenance anaesthesia: inhalational vs intravenous

Nausea and vomiting ‐ subgroup analysis: thiopentone or halothane + N2O versus propofol or propofol + N2O · paediatric

Maintenance anaesthesia: inhalational may leads to higher nausea and vomiting ‐ subgroup analysis: thiopentone or halothane +… compared with intravenous (low certainty).

2 findings from 1 review

Summary of findings: Folic acid vs placebo

Haematological disorders (neutropenia, etc) · Patients receiving methotrexate for rheumatoid arthritis

Folic acid showed no clear difference in haematological disorders (incidence of neutropenia, etc) compared with placebo (low certainty).

1 finding from 1 review

Folic or folinic acid (any) vs placebo

Haematological disorders (neutropenia, etc) · Patients receiving methotrexate for rheumatoid arthritis

Folic or folinic acid (any) showed no clear difference in haematological disorders (neutropenia, etc) compared with placebo (low certainty).

1 finding from 1 review

Intervention not reported

the toxic and side effects of leukopenia after chemotherapy · patients with induction of remission in advanced or late gastric cancer

It is very uncertain whether the intervention changes the toxic and side effects of leukopenia after chemotherapy (very low certainty).

1 finding from 1 review

Intervention not reported

the toxic and side effects of leukopenia after chemotherapy(no special data in trial of Zhang 2006) · patients with induction of remission in advanced or late gastric cancer

It is very uncertain whether the intervention changes the toxic and side effects of leukopenia after chemotherapy(no… (very low certainty).

1 finding from 1 review

Intervention not reported

the toxic and side effects of leukopenia after chemotherapy(no special data in trial of Jia 2003, Zhang 2009) · patients with induction of remission in advanced or late gastric cancer

It is very uncertain whether the intervention changes the toxic and side effects of leukopenia after chemotherapy(no… (very low certainty).

1 finding from 1 review

Intervention not reported

the toxic and side effects of leukopenia after chemotherapy · patients with induction of remission in advanced or late gastric cancer

It is very uncertain whether the intervention changes the toxic and side effects of leukopenia after chemotherapy (very low certainty).

1 finding from 1 review