What do systematic reviews say?

Metabolomics vs non metabolomics

It is very uncertain whether metabolomics changes ectopic pregnancy (a pregnancy in which the fetus develops outside… compared with non metabolomics (very low certainty).

• Metabolomics for improving pregnancy outcomes in women undergoing assisted reproductive technologies 2018 · Cochrane Headline outcomes only
  OR 3 [0.12, 74.07]
  1 study · 417 participants
  Very low

Discontinued intravenous (IV) oxytocin stimulation vs continued IV oxytocin stimulation

Discontinued intravenous (IV) oxytocin stimulation probably leads to lower uterine tachysystole combined with abnormal fetal heart rate compared with continued IV oxytocin stimulation (moderate certainty).

• Discontinuation of intravenous oxytocin in the active phase of induced labour 2018 · Cochrane Headline outcomes only
  RR 0.15
  3 studies · 486 participants
  Moderate

Exercise vs usual care

• Exercise interventions for people undergoing multimodal cancer treatment that includes surgery 2018 · Cochrane Headline outcomes only
  no estimate extracted
  8 studies · 507 participants
  Low

Mirtazapine vs placebo

It is very uncertain whether mirtazapine changes safety: serious adverse events compared with placebo (very low certainty).

• Mirtazapine for fibromyalgia in adults 2018 · Cochrane Headline outcomes only
  RD 0
  3 studies · 606 participants
  Very low

Intervention not reported

The intervention probably leads to higher leukopenia** grade 3 or 4 (safety population) (moderate certainty).

• Platinum‐containing regimens for metastatic breast cancer 2017 · Cochrane Headline outcomes only
  RR 1.38
  22 studies · 3176 participants
  Moderate

Intervention not reported

The intervention probably leads to lower nausea/vomiting* grade 3 or 4 (safety population) by type of… (moderate certainty).

• Platinum‐containing regimens for metastatic breast cancer 2017 · Cochrane Headline outcomes only
  RR 0.77
  7 studies · 1441 participants
  Moderate

Intervention not reported

The intervention leads to higher anaemia grade 3 or 4 (safety population) by type of platinum agent… (high certainty).

• Platinum‐containing regimens for metastatic breast cancer 2017 · Cochrane Headline outcomes only
  RR 1.72
  7 studies · 1441 participants
  High

Intervention not reported

The intervention leads to higher hair loss grade 3 or 4 (safety population) (high certainty).

• Platinum‐containing regimens for metastatic breast cancer 2017 · Cochrane Headline outcomes only
  RR 1.41
  13 studies · 1452 participants
  High

Cardiorespiratory exercise programmes prescribed alone vs a non‐exercise intervention or no intervention

• Fitness training for cardiorespiratory conditioning after traumatic brain injury 2017 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 183 participants
  GRADE not reported

Intracervical PGE₂ vs placebo

Intracervical PGE₂ showed no clear difference in uterine hyperstimulation (with fetal heart rate changes) compared with placebo (low certainty).

• Pharmacological and mechanical interventions for labour induction in outpatient settings 2017 · Cochrane Headline outcomes only
  RR 2.66 [0.63, 11.25]
  4 studies · 488 participants
  Low

Vaginal misoprostol vs placebo

Vaginal misoprostol showed no clear difference in uterine hyperstimulation (with fetal heart rate changes) compared with placebo (low certainty).

• Pharmacological and mechanical interventions for labour induction in outpatient settings 2017 · Cochrane Headline outcomes only
  RR 1.97 [0.43, 9]
  3 studies · 265 participants
  Low

Vaginal PGE₂ vs placebo or expectant management

Vaginal PGE₂ showed no clear difference in uterine hyperstimulation (fetal heart rate changes unclear) compared with placebo or expectant management (low certainty).

• Pharmacological and mechanical interventions for labour induction in outpatient settings 2017 · Cochrane Headline outcomes only
  RR 3.76 [0.64, 22.24]
  4 studies · 244 participants
  Low

Foley catheter vs intravenous (IV) oxytocin

Foley catheter showed no clear difference in uterine hyperstimulation with fetal heart rate changes compared with intravenous (IV) oxytocin (low certainty).

• Methods of term labour induction for women with a previous caesarean section 2017 · Cochrane Headline outcomes only
  RR 3.11 [0.13, 73.09]
  1 study · 53 participants
  Low

Vaginal PGE2 vs intravenous (IV) oxytocin

The review found no eligible studies for this question.

• Methods of term labour induction for women with a previous caesarean section 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Oral mifepristone vs Foley catheter

The review found no eligible studies for this question.

• Methods of term labour induction for women with a previous caesarean section 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Vaginal isosorbide mononitrate vs Foley catheter

The review found no eligible studies for this question.

• Methods of term labour induction for women with a previous caesarean section 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

80 mL vs Foley catheter

The review found no eligible studies for this question.

• Methods of term labour induction for women with a previous caesarean section 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Vaginal misoprostol vs intravenous (IV) oxytocin

The review found no eligible studies for this question.

• Methods of term labour induction for women with a previous caesarean section 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

High‐dose vs low‐dose rFVIIa

• Bypassing agent prophylaxis in people with hemophilia A or B with inhibitors 2017 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 46 participants
  Moderate

Any prophylaxis vs on‐demand therapy with FEIBA

• Bypassing agent prophylaxis in people with hemophilia A or B with inhibitors 2017 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 67 participants
  Low