Findings

What do systematic reviews say?

332 questions · 335 findings · 55 reviews · Headline outcomes only

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No studies found 77 · 23%GRADE not reported 3 · 0.9%Very low 113 · 33.7%Low 75 · 22.4%Moderate 61 · 18.2%High 6 · 1.8%

LC + LCBDE vs pre‐operative ERCP + LC

Total morbidity · with common bile duct stones

LC + LCBDE showed no clear difference in total morbidity compared with pre‐operative ERCP + LC (moderate certainty).

1 finding from 1 review

Surgical versus endoscopic treatment of bile duct stones 2013 · Cochrane Headline outcomes only
OR 1.28 [0.8, 2.05]
5 studies · 580 participants
Moderate

LC + LCBDE vs pre‐operative ERCP + LC

Failure of procedure · with common bile duct stones

LC + LCBDE showed no clear difference in failure of procedure compared with pre‐operative ERCP + LC (moderate certainty).

1 finding from 1 review

Surgical versus endoscopic treatment of bile duct stones 2013 · Cochrane Headline outcomes only
OR 0.51 [0.16, 1.59]
5 studies · 580 participants
Moderate

LC + LCBDE vs pre‐operative ERCP + LC

Retained stones after primary intervention · with common bile duct stones

LC + LCBDE showed no clear difference in retained stones after primary intervention compared with pre‐operative ERCP + LC (moderate certainty).

1 finding from 1 review

Surgical versus endoscopic treatment of bile duct stones 2013 · Cochrane Headline outcomes only
OR 0.79 [0.45, 1.39]
5 studies · 580 participants
Moderate

LC + LCBDE vs pre‐operative ERCP + LC

Conversion to open surgery · with common bile duct stones

LC + LCBDE showed no clear difference in conversion to open surgery compared with pre‐operative ERCP + LC (moderate certainty).

1 finding from 1 review

Surgical versus endoscopic treatment of bile duct stones 2013 · Cochrane Headline outcomes only
OR 1.46 [0.76, 2.81]
5 studies · 580 participants
Moderate

Intervention not reported

Primary outcome: Mortality · Adults (over 18 years) with requirement for an ERCP procedure with diagnostic intent

1 finding from 1 review

Sedative techniques for endoscopic retrograde cholangiopancreatography 2012 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 510 participants
Moderate

Intervention not reported

Primary Outcome: Hypoxaemia · Adults (over 18 years) with requirement for an ERCP procedure with diagnostic intent

1 finding from 1 review

Sedative techniques for endoscopic retrograde cholangiopancreatography 2012 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 510 participants
Moderate

Intervention not reported

Primary Outcome: Hypotension · Adults (over 18 years) with requirement for an ERCP procedure with diagnostic intent

1 finding from 1 review

Sedative techniques for endoscopic retrograde cholangiopancreatography 2012 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 510 participants
Moderate

Intervention not reported

Primary outcome: Failure to complete procedure (due to sedation‐related problems) · Adults (over 18 years) with requirement for an ERCP procedure with diagnostic intent

1 finding from 1 review

Sedative techniques for endoscopic retrograde cholangiopancreatography 2012 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 360 participants
Moderate

Intervention not reported

Secondary outcome: Recovery · Adults (over 18 years) with requirement for an ERCP procedure with diagnostic intent

1 finding from 1 review

Sedative techniques for endoscopic retrograde cholangiopancreatography 2012 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 359 participants
Moderate

Early routine ERCP strategy vs early conservative management with or without delayed or selective ERCP strategy

Death Analysis 1.1 · patients with unselected patients with acute gallstone pancreatitis

Early routine ERCP strategy showed no clear difference in all‐cause mortality, ITT analysis compared with early conservative management with or without delayed or selective… (low certainty).

1 finding from 1 review

Early routine endoscopic retrograde cholangiopancreatography strategy versus early conservative management strategy in… 2012 · Cochrane Headline outcomes only
RR 0.74 [0.18, 3.03]
5 studies · 644 participants
Low

Early routine ERCP strategy vs early conservative management with or without delayed or selective ERCP strategy

Local complications defined by the Atlanta Classification (necrosis, abscess, pseudocyst) · patients with unselected patients with acute gallstone pancreatitis

Early routine ERCP strategy showed no clear difference in local complications defined by the Atlanta Classification (necrosis,… compared with early conservative management with or without delayed or selective… (moderate certainty).

1 finding from 1 review

Early routine endoscopic retrograde cholangiopancreatography strategy versus early conservative management strategy in… 2012 · Cochrane Headline outcomes only
RR 0.86 [0.52, 1.43]
4 studies · 517 participants
Moderate

Early routine ERCP strategy vs early conservative management with or without delayed or selective ERCP strategy

Systemic complications defined by the Atlanta Classification (organ failure including shock, pulmonary insufficiency, renal failure, and gastrointestinal bleeding; disseminated intravascular coagulation or severe metabolic disturbances) · patients with unselected patients with acute gallstone pancreatitis

Early routine ERCP strategy showed no clear difference in systemic complications defined by the Atlanta Classification (organ… compared with early conservative management with or without delayed or selective… (moderate certainty).

1 finding from 1 review

Early routine endoscopic retrograde cholangiopancreatography strategy versus early conservative management strategy in… 2012 · Cochrane Headline outcomes only
RR 0.59 [0.31, 1.11]
4 studies · 406 participants
Moderate