Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

344 questions · 346 findings · 97 reviews · Headline outcomes only

No studies found 31 · 9%GRADE not reported 6 · 1.7%Very low 154 · 44.5%Low 99 · 28.6%Moderate 39 · 11.3%High 17 · 4.9%

Tafamidis vs placebo

Number of participants experiencing at least one severe adverse event · people with early‐stage TTR‐FAP

It is very uncertain whether tafamidis changes number of participants experiencing at least one severe adverse event compared with placebo (very low certainty).

1 finding from 1 review

Chlorhexidine (vaginal wash or gel/cream) vs placebo or no treatment

GBS pneumonia within the first seven days of life · women with vaginal or rectal colonization with GBS during labour and their preterm/term infants

It is very uncertain whether chlorhexidine (vaginal wash or gel/cream) changes GBS pneumonia within the first seven days of life compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Chlorhexidine (vaginal wash or gel/cream) vs placebo or no treatment

Neonatal colonization with GBS within the first seven days of life · women with vaginal or rectal colonization with GBS during labour and their preterm/term infants

It is very uncertain whether chlorhexidine (vaginal wash or gel/cream) changes neonatal colonization with GBS within the first seven days of life compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Chlorhexidine (vaginal wash or gel/cream) vs placebo or no treatment

Adverse (mild) effects in the mother · women with vaginal or rectal colonization with GBS during labour and their preterm/term infants

It is very uncertain whether chlorhexidine (vaginal wash or gel/cream) changes adverse (mild) effects in the mother compared with placebo or no treatment (very low certainty).

1 finding from 1 review