Cochrane · systematic review · CD002308
Early use of inhaled corticosteroids in the emergency department treatment of acute asthma
Edmonds, ML, Milan, SJ, Camargo Jr, CA, et al. · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library
AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 80%Moderate 1 · 20%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
ICS versus placebo
Population: people with acute asthma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Hospital admission ICS vs placebo | OR 0.44 [0.31, 0.61] | 12 studies · 959 participants | Low Downgraded: risk of bias, inconsistency |
FEV1 at 1 hour ICS vs placebo | MD 0.28 | 4 studies · 248 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
FEV1 at 3 to 4 hours ICS vs placebo | MD 0.15 | 4 studies · 319 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Adverse effects ‐ nausea/vomiting ICS vs placebo | OR 0.32 [0.03, 3.18] | 1 study · 94 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
ICS versus systemic corticosteroids
Population: people with acute asthma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Hospital admission ICS vs systemic corticosteroids | OR 0.56 [0.25, 1.24] | 10 studies · 763 participants | Low Downgraded: risk of bias |