Cochrane · systematic review · CD008478
Fertility and early pregnancy outcomes after conservative treatment for cervical intraepithelial neoplasia
Kyrgiou, M, Mitra, A, Arbyn, M, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Gynaecological, Neuro-oncology and Orphan CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 37.5%Low 5 · 62.5%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Fertility outcomes for cervical intraepithelial lesions
Population: patients with cervical intraepithelial lesions
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Total pregnancy rate | RR 1.29 [1.02, 1.64] | 4 studies · 38050 participants | Very low Downgraded: inconsistency |
Pregnancy rate in women with intention to conceive | RR 0.93 [0.8, 1.08] | 2 studies · 70 participants | Very low |
Conception at > 12 months | RR 1.45 [0.89, 2.37] | 3 studies · 1348 participants | Very low Downgraded: risk of bias, inconsistency, publication bias |
Early pregnancy outcomes for cervical intraepithelial lesions
Population: patients with cervical intraepithelial lesions
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Miscarriage rates | RR 1.04 [0.9, 1.21] | 10 studies · 39504 participants | Low Downgraded: imprecision, inconsistency |
1st trimester miscarriage rates | RR 1.16 [0.8, 1.69] | 4 studies · 1103 participants | Low |
2nd trimester miscarriage rates | RR 2.6 [1.45, 4.67] | 8 studies · 2182268 participants | Low Downgraded: imprecision, inconsistency |
Ectopic pregnancy | RR 1.89 [1.5, 2.39] | 6 studies · 38193 participants | Low |
TOP rates | RR 1.71 [1.31, 2.22] | 7 studies · 38208 participants | Low Downgraded: imprecision, inconsistency |