Cochrane · systematic review · CD012847
Obstetric outcomes after conservative treatment for cervical intraepithelial lesions and early invasive disease
Kyrgiou, M, Athanasiou, A, Kalliala, IEJ, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Gynaecological, Neuro-oncology and Orphan CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
12
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 9 · 75%Low 3 · 25%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
The effect of treatment for CIN on maternal outcomes
Population: women with known obstetric outcomes
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
PTB (< 37 w) | RR 1.75 [1.57, 1.96] | 59 studies · 5242917 participants | Very low Downgraded: inconsistency |
PTB (< 32 to 34 w) | RR 2.25 [1.79, 2.82] | 24 studies · 3793874 participants | Very low |
PTB (< 28 to 30 w) | RR 2.23 [1.55, 3.22] | 8 studies · 3910629 participants | Very low Downgraded: inconsistency, publication bias |
PTB (< 37 w) ‐ Repeat cones versus No Treatment | RR 3.78 [2.65, 5.39] | 11 studies · 1317284 participants | Very low Downgraded: inconsistency, publication bias |
pPROM (<3 7 w) | RR 2.36 [1.76, 3.17] | 21 studies · 477011 participants | Very low Downgraded: inconsistency, publication bias |
PTB (< 37 w) ‐ Depth ≤ 10 mm to 12 mm versus No Treatment | RR 1.54 [1.09, 2.18] | 8 studies · 550929 participants | Very low Downgraded: inconsistency, publication bias |
PTB (< 37 w) ‐ PTB (< 37 w) ‐ Depth ≥10 mm to 12 mm versus No Treatment | RR 1.93 [1.62, 2.31] | 8 studies · 552711 participants | Low Downgraded: inconsistency, publication bias |
PTB (< 37w) ‐ PTB (<37w) ‐ Depth ≥15 to 17mm versus No Treatment | RR 2.77 [1.95, 3.93] | 4 studies · 544986 participants | Very low Downgraded: inconsistency, publication bias |
PTB (< 37 w) ‐ PTB (< 37 w) ‐ Depth ≥ 20 mm versus No Treatment | RR 4.91 [2.06, 11.68] | 3 studies · 543750 participants | Very low Downgraded: inconsistency, publication bias |
The effect of treatment for CIN on neonatal outcomes
Population: women with known obstetric outcomes
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
LBW (< 2500 g) ‐ Treatment versus No Treatment | RR 1.81 [1.58, 2.07] | 30 studies · 1348206 participants | Very low Downgraded: inconsistency |
NICU Admission ‐ Treatment versus No Treatment | RR 1.45 [1.16, 1.81] | 8 studies · 2557 participants | Low Downgraded: inconsistency |
Perinatal Mortality ‐ Treatment versus No Treatment | RR 1.51 [1.13, 2.03] | 23 studies · 1659433 participants | Low Downgraded: inconsistency |