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Evidence found and GRADE certainty

4,776 questions · 7,311 findings · 959 reviews · Headline outcomes only

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No studies found 1,498 · 20.5%GRADE not reported 303 · 4.1%Very low 1,839 · 25.2%Low 1,991 · 27.2%Moderate 1,277 · 17.5%High 403 · 5.5%

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Standard care plus IV tranexamic acid vs placebo or usual care

Maternal mortality due to bleeding · women with primary postpartum haemorrhage following vaginal or caesarean birth

Standard care plus IV tranexamic acid showed no clear difference in maternal mortality due to bleeding compared with placebo or standard care alone (moderate certainty).

1 finding from 1 review

Standard care plus IV tranexamic acid vs placebo or usual care

Maternal mortality ‐ not reported · women with primary postpartum haemorrhage following vaginal or caesarean birth

Standard care plus IV tranexamic acid showed no clear difference in maternal mortality (all causes) compared with placebo or standard care alone (moderate certainty).

1 finding from 1 review

Standard care plus IV tranexamic acid vs placebo or usual care

Serious maternal morbidity · women with primary postpartum haemorrhage following vaginal or caesarean birth

Standard care plus IV tranexamic acid showed no clear difference in serious maternal morbidity (any) compared with placebo or standard care alone (high certainty).

1 finding from 1 review

Standard care plus IV tranexamic acid vs placebo or usual care

Maternal blood loss of 500 mL or greater · women with primary postpartum haemorrhage following vaginal or caesarean birth

Standard care plus IV tranexamic acid may leads to lower blood loss 500 mL or more after randomisation compared with placebo or standard care alone (low certainty).

1 finding from 1 review

Standard care plus IV tranexamic acid vs placebo or usual care

Blood transfusion · women with primary postpartum haemorrhage following vaginal or caesarean birth

Standard care plus IV tranexamic acid showed no clear difference in blood transfusion (any) compared with placebo or standard care alone (moderate certainty).

1 finding from 1 review

Standard care plus IV tranexamic acid vs placebo or usual care

Hysterectomy to control bleeding · women with primary postpartum haemorrhage following vaginal or caesarean birth

Standard care plus IV tranexamic acid showed no clear difference in surgical intervention to control bleeding: Hysterectomy compared with placebo or standard care alone (high certainty).

1 finding from 1 review

Standard care plus IV tranexamic acid vs placebo or usual care

Side effects of the intervention: Any maternal vascular occlusive event · women with primary postpartum haemorrhage following vaginal or caesarean birth

Standard care plus IV tranexamic acid showed no clear difference in side effects of the intervention: Any maternal vascular occlusive… compared with placebo or standard care alone (moderate certainty).

1 finding from 1 review

SDAC + hospital intervention vs hospital intervention

Hospitalization · first aid in patients with acute oral poisoning (not specified, tricyclic antidepressants, combinations of different drugs or yellow…

It is very uncertain whether SDAC + hospital intervention changes incidence of hospitalization compared with hospital intervention alone (very low certainty).

1 finding from 1 review

SDAC + hospital intervention vs hospital intervention

Incidence of admissions to the ICU · first aid in patients with acute oral poisoning (not specified, tricyclic antidepressants, combinations of different drugs or yellow…

It is very uncertain whether SDAC + hospital intervention changes incidence of ICU admission compared with hospital intervention alone (very low certainty).

1 finding from 1 review

MDAC + hospital intervention vs SDAC + hospital intervention

Incidence of mortality · first aid in patients with acute oral poisoning (carbamazepine, yellow oleander, or combinations of different drugs)

It is very uncertain whether MDAC + hospital intervention changes incidence of mortality compared with SDAC + hospital intervention (very low certainty).

1 finding from 1 review

MDAC + hospital intervention vs SDAC + hospital intervention

Incidence of adverse events · first aid in patients with acute oral poisoning (carbamazepine, yellow oleander, or combinations of different drugs)

MDAC + hospital intervention may leads to higher incidence of adverse events compared with SDAC + hospital intervention (low certainty).

1 finding from 1 review

MDAC + hospital intervention vs SDAC + hospital intervention

Incidence and severity of symptoms of poisoning: incidence of need for intubation · first aid in patients with acute oral poisoning (carbamazepine, yellow oleander, or combinations of different drugs)

MDAC + hospital intervention showed no clear difference in incidence and severity of symptoms of poisoning: incidence of need… compared with SDAC + hospital intervention (low certainty).

1 finding from 1 review