Participant‐reported sleep problems (scale: 0 to 28; higher scores indicate more sleep problems) · patients with fibromyalgia
Serotonin noradrenaline reuptake inhibitors showed no clear difference in self‐reported sleep problems (0‐100 scale) Higher scores indicate… compared with placebo (low certainty).
1 finding from 1 review
Self‐reported health‐related quality of life (0‐100 scale) Higher scores indicate higher burden of disease (lower quality of life) · patients with fibromyalgia
Serotonin noradrenaline reuptake inhibitors showed no clear difference in self‐reported health‐related quality of life (0‐100 scale) Higher… compared with placebo (low certainty).
1 finding from 1 review
Withdrawals due to adverse events · patients with fibromyalgia
Serotonin noradrenaline reuptake inhibitors may leads to higher tolerability (withdrawal due to adverse events) compared with placebo (low certainty).
1 finding from 1 review
Safety Any serious adverse event · patients with fibromyalgia
It is very uncertain whether serotonin noradrenaline reuptake inhibitors changes safety (serious adverse events) compared with placebo (very low certainty).
1 finding from 1 review
Participant‐reported pain relief of 30% or greater · adults with fibromyalgia
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Participant‐reported pain relief of 50% or greater · adults with fibromyalgia
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Patient Global Impression of Change much or very much improved · adults with fibromyalgia
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Any pain‐related outcome indicating some improvement · adults with fibromyalgia
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Number experiencing adverse effects · adults with fibromyalgia
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Number of participants experiencing any serious adverse events · adults with fibromyalgia
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Withdrawals due to adverse events · adults with fibromyalgia
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Number of migraine days per month: chronic migraine only · adults with migraine
1 finding from 1 review
Number of migraine days per month · adults with migraine
1 finding from 1 review
Number of headache days per month: chronic migraine only · adults with migraine
1 finding from 1 review
Migraine frequency Number of attacks · adults with migraine
1 finding from 1 review
Headache intensity (mean score) · adults with migraine
1 finding from 1 review
Global impression scale · adults with migraine
1 finding from 1 review
Number experiencing adverse effects · adults with migraine
Botulinum toxin type A probably leads to higher total number of participants experiencing an adverse event compared with placebo (moderate certainty).
1 finding from 1 review
Consumption of morphine equivalents 0 to 72 hmg · adults undergoing surgery
1 finding from 1 review
Pain intensity VAS (0 to 100; 0 = no pain, 100 = worst pain) · adults undergoing surgery
1 finding from 1 review