Birthweight (g) · women with obesity during pregnancy
1 finding from 1 review
Live birth rate per woman · Women with polycystic ovary syndrome, oligo amenorrhoea and subfertility
Metformin showed no clear difference in live birth rate per woman compared with placebo or no treatment (low certainty).
1 finding from 1 review
Menstrual frequency per woman · women with polycystic ovary syndrome
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Gastrointestinal adverse events · Women with polycystic ovary syndrome, oligo amenorrhoea and subfertility
Metformin probably leads to higher adverse events (gastrointestinal) per woman compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
Miscarriage · women with polycystic ovary syndrome
It is very uncertain whether metformin changes miscarriage rate per woman compared with clomiphene citrate (very low certainty).
1 finding from 1 review
Clinical pregnancy rate · Women with polycystic ovary syndrome, oligo amenorrhoea and subfertility
Metformin probably leads to higher clinical pregnancy rate per woman compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
Menstrual frequency per woman · Women with polycystic ovary syndrome, oligo amenorrhoea and subfertility
Metformin may leads to higher menstrual frequency per woman compared with placebo or no treatment (low certainty).
1 finding from 1 review
Ovulation rate · Women with polycystic ovary syndrome, oligo amenorrhoea and subfertility
Metformin probably leads to higher ovulation rate per woman compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
Miscarriage · Women with polycystic ovary syndrome, oligo amenorrhoea and subfertility
Metformin showed no clear difference in miscarriage rate per woman compared with placebo or no treatment (low certainty).
1 finding from 1 review
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · people with cancer pain
Methadone may leads to higher participant‐reported pain intensity compared with morphine (low certainty).
1 finding from 1 review
Adverse events: appetite, thirst, somnolence · people with cancer pain
1 finding from 1 review
Live birth rate per woman · subfertile women with polycystic ovary syndrome
Metformin may leads to higher live birth rate (per woman) compared with placebo co‐treatment (low certainty).
1 finding from 1 review
Multiple pregnancy rate · subfertile women with polycystic ovary syndrome
Metformin showed no clear difference in multiple pregnancy rate (per woman) compared with placebo co‐treatment (low certainty).
1 finding from 1 review
Ongoing pregnancy · subfertile women with polycystic ovary syndrome
Metformin may leads to higher ongoing pregnancy rate (per woman) compared with placebo co‐treatment (low certainty).
1 finding from 1 review
Clinical pregnancy rate · subfertile women with polycystic ovary syndrome
Metformin may leads to higher clinical pregnancy rate (per woman) compared with placebo co‐treatment (low certainty).
1 finding from 1 review
Moderate benefit: At least 30% reduction in pain, or PGIC much or very much improved · adults with chronic neuropathic pain
1 finding from 1 review
Substantial benefit: At least 50% reduction in pain, or PGIC much improved · adults with chronic neuropathic pain
1 finding from 1 review
Lack of efficacy withdrawal · adults with chronic neuropathic pain
1 finding from 1 review
Withdrawals due to adverse events · adults with chronic neuropathic pain
1 finding from 1 review
Participants experiencing anyserious adverseevents · adults with chronic neuropathic pain
1 finding from 1 review
no estimate extracted
Studies not reported
Very low