Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

339 questions · 355 findings · 25 reviews

No studies found 134 · 37.7%GRADE not reported 38 · 10.7%Very low 87 · 24.5%Low 66 · 18.6%Moderate 27 · 7.6%High 3 · 0.8%

High-viscosity glass-ionomer ART restorations vs Conventional treatment using RM-GIC

Restoration failure (permanent, mature teeth) · Adults with root caries in permanent (mature) teeth

ART using H-GIC showed no clear difference in restoration failure (permanent, mature teeth) compared with conventional treatment using RM-GIC (with local anaesthetic); GRADE not reported.

1 finding from 1 review

Preoperative ibuprofen vs placebo

Postoperative pain (continuous measure: self report using visual analogue scale) · Children and adolescents having orthodontic separator placement (without local anaesthetic)

Preoperative ibuprofen may leads to lower postoperative pain (continuous measure: self report using visual… compared with placebo (low certainty).

1 finding from 1 review

Preoperative ibuprofen vs placebo

Adverse events · Children and adolescents having orthodontic separator placement (without local anaesthetic)
1 finding from 1 review

Preoperative paracetamol (acetaminophen) vs placebo

Postoperative pain (dichotomous measure: parent report of presence of pain-related behaviours) · Children and adolescents having dental treatment under local anaesthetic (restorative and extraction treatments)

Preoperative paracetamol (acetaminophen) showed no clear difference in postoperative pain (dichotomous measure: parent report of presence… compared with placebo (low certainty).

1 finding from 1 review

Thoracic epidural anaesthesia vs conventional pain control

Persistent pain 3 to 18 months after thoracotomy (We defined persistent postsurgical pain as new pain that did not exist before the operation, measured using differences in scores based on validated pain scales; patient interview between 3 to 18 m... · Patients undergoing thoracotomy

Thoracic epidural anaesthesia probably leads to lower persistent pain 3 to 18 months after thoracotomy (We defined… compared with conventional pain control (moderate certainty).

1 finding from 1 review

Regional anaesthesia vs conventional pain control

Persistent pain 3 to 12 months after breast cancer surgery (We defined persistent postsurgical pain as new pain that did not exist before the operation, measured using differences in scores based on validated pain scales; patient interview between... · women with breast cancer undergoing elective surgery

Regional anaesthesia may leads to lower persistent pain 3 to 12 months after breast cancer surgery (We… compared with conventional pain control (low certainty).

1 finding from 1 review

Intervention not reported

Persistent pain 3 to 8 months after caesarean section (We defined persistent postsurgical pain as new pain that did not exist before the operation, measured using differences in scores based on validated pain scales; patient interview between 3 to... · women after caesarean section

The intervention probably leads to lower persistent pain 3 to 8 months after caesarean section (We defined… (moderate certainty).

1 finding from 1 review

Intervention not reported

Persistent pain 3 to 55 months after iliac crest bone graft harvesting (We defined persistent postsurgical pain as new pain that did not exist before the operation, measured using differences in scores based on validated pain scales; patient inter... · people after iliac crest bone graft harvesting

The intervention showed no clear difference in persistent pain 3 to 55 months after iliac crest bone graft… (low certainty).

1 finding from 1 review

Intervention not reported

Persistent pain 3 to 6 months after breast cancer surgery (We defined persistent postsurgical pain as new pain that did not exist before the operation, measured using differences in scores based on validated pain scales; patient interview between ... · women with breast cancer undergoing elective surgery

The intervention probably leads to lower persistent pain 3 to 6 months after breast cancer surgery (We… (moderate certainty).

1 finding from 1 review