Incidence and severity of treatment‐related adverse effects ‐ fractional carbon dioxide (CO2) laser versus TAC ‐ pain at injection site ‐ keloid scars ‐ · participants with hypertrophic and keloid scars
It is very uncertain whether laser therapy changes incidence and severity of treatment‐related adverse effects ‐… compared with other treatments (very low certainty).
1 finding from 1 review
RR 0.25 [0.06, 1.03]
Studies not reported
Very low
Incidence and severity of treatment‐related adverse effects ‐ fractional CO2 laser versus verapamil ‐ pain at injection site ‐ keloid scars ‐ · participants with hypertrophic and keloid scars
It is very uncertain whether laser therapy changes incidence and severity of treatment‐related adverse effects ‐… compared with other treatments (very low certainty).
1 finding from 1 review
RR 5
Studies not reported
Very low
Injection site pain · hormone‐sensitive prostate cancer
Degarelix probably leads to higher injection site pain compared with standard androgen suppression therapy (moderate certainty).
1 finding from 1 review
Severe nocturnal hypoglycaemia (n/N) Definition: severe hypoglycaemia occurring 00:01‐05:59 (Davies 2014) or 23:00‐07:00 (BEGIN Young)
Summary of findings: insulin glargine showed no clear difference in severe nocturnal hypoglycaemia (n/N) Definition: severe… compared with NPH insulin (moderate certainty).
1 finding from 1 review
Intervention not reported
Cost of analgesic regimens for single‐injection blocks · patients with hip fracture
1 finding from 1 review
Number of anti‐VEGF injections · people with neovascular AMD
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Number of anti‐VEGF injections · people with neovascular AMD
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Proportion of participants experiencing conjunctival injection (redness) at 4–6 weeks · Demodex blepharitis
1 finding from 1 review
Adverse effects: pain on injection (solution deposition), Heft-Parker VAS 0-170 mm · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia
Counter-stimulation or distraction led to lower pain on injection (Wong-Baker Faces / TPPPS / FPS-R, after LA) compared with conventional treatment; GRADE not reported.
1 finding from 1 review
MD -3.18 [-4.26, -2.10]
1 study
GRADE not reported
Adverse effects: pain on injection (solution deposition), Heft-Parker VAS 0-170 mm · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia
Audiovisual distraction showed no clear difference in pain on injection (Wong-Baker Faces Pain Rating Scale, after… compared with conventional treatment; GRADE not reported.
1 finding from 1 review
MD 0.04 [-0.41, 0.48]
1 study
GRADE not reported
Adverse effects: pain on injection (solution deposition), Heft-Parker VAS 0-170 mm · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia
The wand (computer-controlled LA delivery system) showed no clear difference in pain on injection (self-reported; FACES Pain Scale Revised) compared with sleeper One (electronic LA delivery system); GRADE not reported.
1 finding from 1 review
Number of kidneys with temporary renal dilatation after injection · primary VUR
Macroplastique may leads to higher number of kidneys with temporary renal dilatation after injection compared with dextranomer/hyaluronic acid polymer (Deflux) to correct… (low certainty).
1 finding from 1 review
Adherence to method use as indicated by on‐time injections overall · Women of reproductive age seeking to avoid pregnancy
Reminders (+/‐ educational information) showed no clear difference in adherence to method use as indicated by on‐time injections overall compared with usual family planning care (low certainty).
1 finding from 1 review
Adverse effects after treatment initiation: injection site reactions, neutropenia, infections, demyelinating disease, heart failure, malignancy, and induction of autoimmunity. · children diagnosed with Kawasaki disease
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Prostatitis symptoms Subgroup: Intraprostatic injection, participants age > 50 years old, basal NIH‐CPSI score > 30 · participants with chronic prostatitis/chronic pelvic pain syndrome
1 finding from 1 review
Prostatitis symptoms Subgroup: Pelvic floor muscles injection, participants age < 50 years old, basal NIH‐CPSI score < 30 · participants with chronic prostatitis/chronic pelvic pain syndrome
1 finding from 1 review
Overall local/injection site adverse events · 9‐ to 14‐year‐old females and males
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Overall local/injection site adverse events at 15‐day · 10‐ to 26‐year‐old males
Three doses HPV vaccine leads to higher overall local/injection site adverse events at 15‐day compared with control (high certainty).
1 finding from 1 review
Overall local/injection site adverse events at 15‐day · 9‐ to 26‐year‐old females and males
Nonavalent HPV vaccine leads to higher overall local/injection site adverse events at 15‐day compared with quadrivalent HPV vaccine (high certainty).
1 finding from 1 review
Overall local/injection site adverse events · 9‐ to 15‐year‐old females
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found