What do systematic reviews say?

Summary of findings table ‐ Exercise plus usual pharmacological care vs usual pharmacological care alone

• Exercise as adjunctive therapy for systemic lupus erythematosus 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 104 participants
  Low

Summary of findings table ‐ Exercise plus usual pharmacological care vs usual pharmacological care alone

• Exercise as adjunctive therapy for systemic lupus erythematosus 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 96 participants
  Low

Intervention not reported

• Exercise therapy for fatigue in multiple sclerosis 2015 · Cochrane Headline outcomes only
  no estimate extracted
  27 studies · 1325 participants
  Moderate

Intervention not reported

• Exercise therapy for fatigue in multiple sclerosis 2015 · Cochrane Headline outcomes only
  no estimate extracted
  9 studies · 278 participants
  Low

Coenzyme Q10 vs placebo or conventional therapy

• Coenzyme Q10 for heart failure 2021 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 91 participants
  Very low

Autogenic drainage vs conventional physiotherapy

The review found no eligible studies for this question.

• Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings ‐ PEP vs oscillating PEP

• Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 68 participants
  Moderate

Summary of findings ‐ PEP vs HFCWO

The review found no eligible studies for this question.

• Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings ‐ PEP vs BiPAP

• Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 32 participants
  Low

Summary of findings ‐ PEP vs airway clearance techniques

• Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 45 participants
  Low

Summary of findings ‐ PEP vs PDPV

• Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 66 participants
  Low

Transmyocardial laser revascularization vs medical treatment

• Transmyocardial laser revascularization versus medical therapy for refractory angina 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 129 participants
  Moderate

Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy)

The review found no eligible studies for this question.

• Occlusal interventions for managing temporomandibular disorders 2024 · Cochrane All outcomes
  Listed in Summary of findings 3 as 'Not reported'; this outcome was not reported by any included study for this comparison.
  0 studies
  No studies found

Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy)

The review found no eligible studies for this question.

• Occlusal interventions for managing temporomandibular disorders 2024 · Cochrane All outcomes
  Listed in Summary of findings 3 as 'Not reported'; this outcome was not reported by any included study for this comparison.
  0 studies
  No studies found

Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy)

Occlusal splint showed no clear difference in depression compared with physical therapy (ultrasound, exercise, sensorimotor training,…; GRADE not reported.

• Occlusal interventions for managing temporomandibular disorders 2024 · Cochrane All outcomes

  Short term · Disc displacement with reduction (DDwR)
  MD -0.25 [-0.52, 0.02]
  1 study · 60 participants
  GRADE not reported

Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy)

It is very uncertain whether occlusal splint changes severity of joint noise compared with physical therapy (ultrasound, exercise, sensorimotor training,… (very low certainty).

• Occlusal interventions for managing temporomandibular disorders 2024 · Cochrane All outcomes

  Long term (4 months) · Mixed TMD
  MD 5.92 [0.18, 11.66]
  1 study · 20 participants
  Very low

Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy)

Occlusal splint led to lower participant satisfaction or quality of life compared with physical therapy (ultrasound, exercise, sensorimotor training,…; GRADE not reported.

• Occlusal interventions for managing temporomandibular disorders 2024 · Cochrane All outcomes

  Short term (1 month) · Mixed TMD
  MD -7.56 [-14.50, -0.63]
  2 studies · 75 participants
  GRADE not reported

Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy)

It is very uncertain whether occlusal splint changes muscle pain when chewing compared with physical therapy (ultrasound, exercise, sensorimotor training,… (very low certainty).

• Occlusal interventions for managing temporomandibular disorders 2024 · Cochrane All outcomes

  Short term (mean 3 months) · Myofascial pain TMD
  RR 0.17 [0.02, 1.26]
  1 study · 40 participants
  Very low

Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy)

It is very uncertain whether occlusal splint changes joint pain at rest compared with physical therapy (ultrasound, exercise, sensorimotor training,… (very low certainty).

• Occlusal interventions for managing temporomandibular disorders 2024 · Cochrane All outcomes

  Short term (6 weeks) · Disc displacement without reduction (DDwoR)
  RR 0.85 [0.47, 1.57]
  1 study · 31 participants
  Very low

Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy)

It is very uncertain whether occlusal splint changes frequency of joint noise compared with physical therapy (ultrasound, exercise, sensorimotor training,… (very low certainty).

• Occlusal interventions for managing temporomandibular disorders 2024 · Cochrane All outcomes

  Short term (3 months) · Myofascial pain TMD
  RR 1.50 [0.32, 6.94]
  1 study · 18 participants
  Very low