What do systematic reviews say?

Bexarotene + PUVA vs PUVA

Bexarotene + PUVA showed no clear difference in objective response rate (Time point of measurement: up to 16 weeks) compared with PUVA alone (low certainty).

• Interventions for mycosis fungoides 2020 · Cochrane Headline outcomes only
  RR 0.94 [0.61, 1.44]
  1 study · 93 participants
  Low

IFN‐α + PUVA vs PUVA

The review found no eligible studies for this question.

• Interventions for mycosis fungoides 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

IFN‐α + PUVA vs PUVA

The review found no eligible studies for this question.

• Interventions for mycosis fungoides 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Daily conventionally fractionated radiotherapy vs supportive care

• External beam radiation dose escalation for high grade glioma 2020 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 289 participants
  GRADE not reported

Laxative plus bulking agent vs laxative alone

It is very uncertain whether laxative plus bulking agent changes adverse effects on women: faecal incontinence during first 10… compared with laxative alone (very low certainty).

• Interventions for preventing postpartum constipation 2020 · Cochrane Headline outcomes only
  RR 1.81 [1.01, 3.23]
  1 study · 147 participants
  Very low

Laxative plus bulking agent vs laxative alone

The review found no eligible studies for this question.

• Interventions for preventing postpartum constipation 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Topical antibiotics with steroids vs topical antibiotics

• Topical antibiotics with steroids for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 395 participants
  Very low

Topical antibiotics with steroids vs topical antibiotics

It is very uncertain whether topical antibiotics with steroids changes suspected ototoxicity: dizziness/vertigo/balance compared with topical antibiotics alone (very low certainty).

• Topical antibiotics with steroids for chronic suppurative otitis media 2020 · Cochrane Headline outcomes only
  RR 0.46 [0.04, 4.8]
  1 study · 52 participants
  Very low

PPI plus usual care vs usual care alone or chronic obstructive pulmonary disease

It is very uncertain whether PPI plus usual care changes acute respiratory infections study duration: 12 months compared with usual care alone or chronic obstructive pulmonary disease (very low certainty).

• Proton pump inhibitors for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
  RR 0.96 [0.67, 1.39]
  1 study · 100 participants
  Very low

Flossing plus toothbrushing vs Toothbrushing alone

• Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal… 2019 · Cochrane All outcomes
  Adverse effects were assessed and reported in seven studies. Three reported no adverse events on the oral hard or soft tissues. Four reported sporadic adverse events with mild severity, with no evidence of a difference…
  7 studies
  GRADE not reported

Combined HBO and perioperative antibiotics prior to dental implant therapy vs antibiotics alone

• Interventions for preventing osteoradionecrosis of the jaws in adults receiving head and neck radiotherapy 2019 · Cochrane All outcomes

  1 year
  This comparison was only made in 1 study which reported no serious adverse events associated with HBO therapy. Quality of life measures (oral status, functioning, satisfaction) showed emotional functioning and pain…
  1 study · 26 participants
  Very low

Oral irrigation plus toothbrushing vs Toothbrushing alone

• Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal… 2019 · Cochrane All outcomes
  Three studies reported that there were no adverse events, one reported one incidence of aphthous ulcer in irrigator group, one reported oral lacerations but found no difference between the interventions, and one did…
  5 studies
  GRADE not reported

Rubber/elastomeric cleaning stick plus toothbrushing vs Toothbrushing alone

The review found no eligible studies for this question.

• Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal… 2019 · Cochrane All outcomes
  Harms and adverse outcomes: Not reported (neither study reported on adverse effects).
  0 studies
  No studies found

Antidepressants plus benzodiazepines vs antidepressants alone

Antidepressants plus benzodiazepines probably leads to lower adverse effects (dropouts) compared with antidepressants alone (moderate certainty).

• Antidepressants plus benzodiazepines for adults with major depression 2019 · Cochrane Headline outcomes only
  RR 0.54 [0.32, 0.9]
  10 studies · 731 participants
  Moderate

Abdominal paracentesis and intraperitoneal infusion of catumaxomab vs abdominal paracentesis alone

The review found no eligible studies for this question.

• Management of drainage for malignant ascites in gynaecological cancer 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

GnRH agonist plus chemotherapy vs chemotherapy alone

It is very uncertain whether gnRH agonist plus chemotherapy changes adverse effects: hot flush compared with chemotherapy alone (very low certainty).

• Adjuvant gonadotropin‐releasing hormone analogues for the prevention of chemotherapy‐induced premature ovarian failure… 2019 · Cochrane Headline outcomes only
  RR 1.49 [0.16, 13.6]
  4 studies · 731 participants
  Very low

GnRH agonist plus chemotherapy vs chemotherapy alone

GnRH agonist plus chemotherapy showed no clear difference in adverse effects: vaginal dryness compared with chemotherapy alone (moderate certainty).

• Adjuvant gonadotropin‐releasing hormone analogues for the prevention of chemotherapy‐induced premature ovarian failure… 2019 · Cochrane Headline outcomes only
  RR 1.18 [0.68, 2.04]
  2 studies · 488 participants
  Moderate

Topical cyclosporine A 0.05% + artificial tears vs vehicle + artificial tears or artificial tears alone

• Topical cyclosporine A therapy for dry eye syndrome 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 56 participants
  Low

Pelvic floor muscle training (PFMT) with urotherapy vs urotherapy alone

The review found no eligible studies for this question.

• Conservative interventions for treating functional daytime urinary incontinence in children 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Voiding education with uroflow feedback and urotherapy vs urotherapy alone

The review found no eligible studies for this question.

• Conservative interventions for treating functional daytime urinary incontinence in children 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found