Cochrane · systematic review · CD008946
Interventions for mycosis fungoides
Valipour, A, Jäger, M, Wu, P, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
SkinAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
20
current version
GRADE rated
9
No studies
7
Included studies
NR
No studies 7 · 35%Ungraded 4 · 20%Very low 3 · 15%Low 6 · 30%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
IFN‐α + PUVA compared to PUVA alone for mycosis fungoides
Population: people with mycosis fungoides
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Improvement of quality of life IFN‐α + PUVA vs PUVA alone | no estimate extracted | NR | No studies |
Common adverse effects IFN‐α + PUVA vs PUVA alone | no estimate extracted | NR | No studies |
Complete response (CR) IFN‐α + PUVA vs PUVA alone | RR 1.07 [0.87, 1.31] | 2 studies · 122 participants | Low Downgraded: risk of bias, imprecision |
Objective response rate (ORR) IFN‐α + PUVA vs PUVA alone | no estimate extracted | NR | No studies |
Extracorporeal photopheresis compared to PUVA for mycosis fungoides
Population: people with mycosis fungoides
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Improvement of quality of life Extracorporeal photopheresis vs PUVA | no estimate extracted | NR | No studies |
Common adverse effects (Time point of measurement: three months of PUVA or six months of ECPc) Extracorporeal photopheresis vs PUVA | no estimate extracted | 1 study · 16 participants | Very low Downgraded: risk of bias, imprecision |
Complete response (Time point of measurement: three months of PUVA or six months of ECPc) Extracorporeal photopheresis vs PUVA | RR 0.2 [0.01, 3.61] | 1 study · 16 participants | Very low Downgraded: risk of bias, imprecision |
Objective response rate (Time point of measurement: three months of PUVA or six months of ECPc) Extracorporeal photopheresis vs PUVA | RR 0.08 [0.01, 1.17] | 1 study · 16 participants | Very low Downgraded: risk of bias, imprecision |
Bexarotene + PUVA compared to PUVA alone for mycosis fungoides
Population: people with mycosis fungoides
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Improvement of quality of life Bexarotene + PUVA vs PUVA alone | no estimate extracted | NR | No studies |
Common adverse effects ‐ Photosensitivity (Time point of measurement: up to 16 weeks) Bexarotene + PUVA vs PUVA alone | RR 2.68 [0.11, 64.04] | 1 study · 87 participants | Low Downgraded: risk of bias, imprecision |
Complete response (Time point of measurement: up to 16 weeks) Bexarotene + PUVA vs PUVA alone | RR 1.41 [0.71, 2.8] | 1 study · 93 participants | Low Downgraded: risk of bias, imprecision |
Objective response rate (Time point of measurement: up to 16 weeks) Bexarotene + PUVA vs PUVA alone | RR 0.94 [0.61, 1.44] | 1 study · 93 participants | Low Downgraded: risk of bias, imprecision |
IFN‐α + acitretin compared to IFN‐α + PUVA for mycosis fungoides
Population: people with mycosis fungoides
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Improvement of quality of life IFN‐α + acitretin vs IFN‐α + PUVA | no estimate extracted | NR | No studies |
Common adverse effects ‐ Flu‐like symptoms (Time point of measurement: up to 48 weeks or until complete response) IFN‐α + acitretin vs IFN‐α + PUVA | RR 1.32 [0.92, 1.88] | 1 study · 82 participants | Low Downgraded: risk of bias, imprecision |
Complete response (Time point of measurement: up to 48 weeks or until complete response) IFN‐α + acitretin vs IFN‐α + PUVA | RR 0.54 [0.35, 0.84] | 1 study · 82 participants | Low Downgraded: risk of bias, imprecision |
Objective response rate IFN‐α + acitretin vs IFN‐α + PUVA | no estimate extracted | NR | No studies |
PUVA maintenance compared to no maintenance for mycosis fungoides
Population: mycosis fungoides
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Improvement of quality of life PUVA maintenance vs no maintenance | no estimate extracted | 1 study · 1 participants | Ungraded |
Common adverse effects PUVA maintenance vs no maintenance | no estimate extracted | 1 study · 1 participants | Ungraded |
Complete response PUVA maintenance vs no maintenance | no estimate extracted | 1 study · 1 participants | Ungraded |
Objective response rate PUVA maintenance vs no maintenance | no estimate extracted | 1 study · 1 participants | Ungraded |