Findings

What do systematic reviews say?

695 questions · 728 findings · 63 reviews · Headline outcomes only

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No studies found 219 · 30.1%GRADE not reported 55 · 7.6%Very low 194 · 26.6%Low 136 · 18.7%Moderate 90 · 12.4%High 34 · 4.7%

Cannabidiol vs placebo

IBDQ at week 6 · people with active UC

1 finding from 1 review

Cannabis for the treatment of ulcerative colitis 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 53 participants
Moderate

Cannabidiol vs placebo

Adverse events · people with active UC

Cannabidiol probably leads to higher adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Cannabis for the treatment of ulcerative colitis 2018 · Cochrane Headline outcomes only
RR 1.28 [1.05, 1.56]
1 study · 60 participants
Moderate

Cannabidiol vs placebo

Serious adverse events · people with active UC

Cannabidiol showed no clear difference in serious adverse events compared with placebo (low certainty).

1 finding from 1 review

Cannabis for the treatment of ulcerative colitis 2018 · Cochrane Headline outcomes only
RR 0.15 [0.01, 2.83]
1 study · 60 participants
Low

Cannabidiol vs placebo

Withdrawals due to adverse events · people with active UC

Cannabidiol showed no clear difference in withdrawal due to adverse event compared with placebo (low certainty).

1 finding from 1 review

Cannabis for the treatment of ulcerative colitis 2018 · Cochrane Headline outcomes only
RR 2.14 [0.83, 5.51]
1 study · 60 participants
Low

Cannabis cigarettes vs placebo

Clinical remission · people with active UC

The review found no eligible studies for this question.

1 finding from 1 review

Cannabis for the treatment of ulcerative colitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Cannabis cigarettes vs placebo

Clinical response · people with active UC

The review found no eligible studies for this question.

1 finding from 1 review

Cannabis for the treatment of ulcerative colitis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Primary outcome: topical local anaesthetics vs infiltrated local anaesthetics or other topical agents

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · adults and paediatric patients with dermal laceration

5 findings from 1 review

Topical anaesthetics for pain control during repair of dermal laceration 2017 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 1006 participants
Low
Topical anaesthetics for pain control during repair of dermal laceration 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 530 participants
Low
Topical anaesthetics for pain control during repair of dermal laceration 2017 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 543 participants
Low

Show 2 more findings

Topical anaesthetics for pain control during repair of dermal laceration 2017 · Cochrane Headline outcomes only
no estimate extracted
11 studies · 1231 participants
Low
Topical anaesthetics for pain control during repair of dermal laceration 2017 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 656 participants
Low

Primary outcome: topical local anaesthetics vs infiltrated local anaesthetics or other topical agents

Anaesthetic‐related adverse effects · adults and paediatric patients with dermal laceration

Primary outcome: topical local anaesthetics led to lower anaesthetic‐related adverse effects compared with infiltrated local anaesthetics or other topical agents; GRADE not reported.

1 finding from 1 review

Topical anaesthetics for pain control during repair of dermal laceration 2017 · Cochrane Headline outcomes only
RR 0 [0, 0]
11 studies · 1686 participants
GRADE not reported

Intervention not reported

Participant self‐reported VAS (0‐100 mm) pain scores · treatment repair of dermal laceration

1 finding from 1 review

Topical anaesthetics for pain control during repair of dermal laceration 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 240 participants
Low

Azathioprine vs placebo

Failure to maintain remission · Patients with quiescent ulcerative colitis

Azathioprine may leads to lower failure to maintain remission compared with placebo (low certainty).

1 finding from 1 review

Azathioprine and 6‐mercaptopurine for maintenance of remission in ulcerative colitis 2016 · Cochrane Headline outcomes only
RR 0.68 [0.54, 0.86]
4 studies · 232 participants
Low

Intervention not reported

Acute pancreatitis · Patients with quiescent ulcerative colitis

It is very uncertain whether the intervention changes acute pancreatitis (very low certainty).

1 finding from 1 review

Azathioprine and 6‐mercaptopurine for maintenance of remission in ulcerative colitis 2016 · Cochrane Headline outcomes only
RR 4.13 [0.48, 35.48]
6 studies · 279 participants
Very low

Intervention not reported

Bone marrow suppression · Patients with quiescent ulcerative colitis

It is very uncertain whether the intervention changes bone marrow suppression (very low certainty).

1 finding from 1 review

Azathioprine and 6‐mercaptopurine for maintenance of remission in ulcerative colitis 2016 · Cochrane Headline outcomes only
RR 3.09 [0.64, 14.83]
5 studies · 257 participants
Very low

Azathioprine vs placebo

Any adverse events · Patients with quiescent ulcerative colitis

It is very uncertain whether azathioprine changes any adverse events compared with placebo (very low certainty).

1 finding from 1 review

Azathioprine and 6‐mercaptopurine for maintenance of remission in ulcerative colitis 2016 · Cochrane Headline outcomes only
RR 2.51 [0.82, 7.74]
4 studies · 232 participants
Very low

Azathioprine vs placebo

Withdrawals due to adverse events · Patients with quiescent ulcerative colitis

It is very uncertain whether azathioprine changes withdrawal due to adverse event compared with placebo (very low certainty).

1 finding from 1 review

Azathioprine and 6‐mercaptopurine for maintenance of remission in ulcerative colitis 2016 · Cochrane Headline outcomes only
RR 7 [0.38, 128.87]
3 studies · 152 participants
Very low

Azathioprine vs sulfasalazine

Failure to maintain remission · Patients with quiescent ulcerative colitis

It is very uncertain whether azathioprine changes failure to maintain remission compared with sulfasalazine (very low certainty).

1 finding from 1 review

Azathioprine and 6‐mercaptopurine for maintenance of remission in ulcerative colitis 2016 · Cochrane Headline outcomes only
RR 1.52 [0.66, 3.5]
1 study · 25 participants
Very low

6‐Mercaptopurine vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Failure to maintain remission · Patients with quiescent ulcerative colitis

It is very uncertain whether 6‐Mercaptopurine changes failure to maintain remission compared with 5‐ASA (very low certainty).

1 finding from 1 review

Azathioprine and 6‐mercaptopurine for maintenance of remission in ulcerative colitis 2016 · Cochrane Headline outcomes only
RR 0.53 [0.31, 0.9]
1 study · 22 participants
Very low

6‐Mercaptopurine vs methotrexate

Failure to maintain remission · Patients with quiescent ulcerative colitis

It is very uncertain whether 6‐Mercaptopurine changes failure to maintain remission compared with methotrexate (very low certainty).

1 finding from 1 review

Azathioprine and 6‐mercaptopurine for maintenance of remission in ulcerative colitis 2016 · Cochrane Headline outcomes only
RR 0.55 [0.31, 0.95]
1 study · 26 participants
Very low

Azathioprine vs cyclosporin of remission

Failure to maintain remission · Patients with quiescent ulcerative colitis

It is very uncertain whether azathioprine (AZA) changes failure to maintain remission compared with cyclosporin of remission (very low certainty).

1 finding from 1 review

Azathioprine and 6‐mercaptopurine for maintenance of remission in ulcerative colitis 2016 · Cochrane Headline outcomes only
RR 0.8 [0.33, 1.92]
1 study · 16 participants
Very low

Intervention not reported

Any adverse event · Patients with quiescent ulcerative colitis

It is very uncertain whether the intervention changes any adverse event (very low certainty).

1 finding from 1 review

Azathioprine and 6‐mercaptopurine for maintenance of remission in ulcerative colitis 2016 · Cochrane Headline outcomes only
RR 2.82 [0.99, 8.01]
5 studies · 257 participants
Very low

Intervention not reported

Withdrawal due to adverse event · Patients with quiescent ulcerative colitis

It is very uncertain whether the intervention changes withdrawal due to adverse event (very low certainty).

1 finding from 1 review

Azathioprine and 6‐mercaptopurine for maintenance of remission in ulcerative colitis 2016 · Cochrane Headline outcomes only
RR 5.43 [1.02, 28.75]
5 studies · 199 participants
Very low