Glyceryl trinitrate (GTN) leads to higher adverse event: Headache, on treatment (7‐12 days) compared with no GTN (high certainty).
Inhaled NO leads to lower death or use of ECMO; studies that did not allow back‐up use of iNO… compared with control (high certainty).
Inhaled NO at moderate showed no clear difference in use of ECMO before hospital discharge compared with severe criteria (moderate certainty).
Inhaled NO at moderate probably leads to lower progression to severe criteria compared with severe criteria (moderate certainty).
Inhaled NO at moderate showed no clear difference in neurodevelopmental disability at 18 to 24 months among survivors compared with severe criteria (moderate certainty).
Inhaled NO showed no clear difference in death or use of ECMO; infants with diaphragmatic hernia compared with control (moderate certainty).
Inhaled NO showed no clear difference in death before hospital discharge; studies that did not allow back‐up… compared with control (high certainty).
Inhaled NO showed no clear difference in death before hospital discharge; infants with diaphragmatic hernia compared with control (moderate certainty).
Inhaled NO leads to lower use of ECMO before hospital discharge; studies that did not allow… compared with control (high certainty).
Inhaled NO showed no clear difference in use of ECMO before hospital discharge; infants with diaphragmatic… compared with control (moderate certainty).
Inhaled NO showed no clear difference in neurodevelopmental disability at 18 to 24 months among survivors compared with control (low certainty).
Inhaled NO at moderate showed no clear difference in death or requirement for ECMO compared with severe criteria (low certainty).
Inhaled NO at moderate showed no clear difference in death before hospital discharge compared with severe criteria (moderate certainty).
Inhaled NO showed no clear difference in death before discharge ‐ Studies with entry before 3 days based on… compared with control (high certainty).
Inhaled NO showed no clear difference in neurodevelopmental disability ‐ Studies with entry after 3 days… compared with control (moderate certainty).
Inhaled NO showed no clear difference in death or bronchopulmonary dysplasia at 36 weeks ‐ Studies with entry… compared with control (high certainty).
Inhaled NO showed no clear difference in death or bronchopulmonary dysplasia at 36 weeks ‐ Studies with entry… compared with control (high certainty).
Mortality with anti‐gram‐positive antibiotics showed no clear difference in overall mortality compared with placebo (moderate certainty).
Treatment failure with anti‐gram‐positive antibiotics showed no clear difference in overall failure (disregarding modifications) compared with placebo (low certainty).
It is very uncertain whether treatment failure with anti‐gram‐positive antibiotics changes failure, modifications included compared with placebo (very low certainty).