Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

880 questions · 912 findings · 126 reviews · Headline outcomes only

No studies found 143 · 15.7%GRADE not reported 38 · 4.2%Very low 250 · 27.4%Low 253 · 27.7%Moderate 168 · 18.4%High 60 · 6.6%

Nasal interfaces (single nasal prong, binasal prongs (long or short), or nasal masks) vs face mask

Intubation and mechanical ventilation in the DR · term and preterm infants resuscitated at birth, using positive pressure ventilation

It is very uncertain whether nasal interfaces (single nasal prong, binasal prongs (long or… changes intubation and mechanical ventilation in the DR compared with face mask (very low certainty).

1 finding from 1 review

Nasal interfaces (single nasal prong, binasal prongs (long or short), or nasal masks) vs face mask

Intubation and mechanical ventilationwithin 24 hours of birth · term and preterm infants resuscitated at birth, using positive pressure ventilation

It is very uncertain whether nasal interfaces (single nasal prong, binasal prongs (long or… changes intubation and mechanical ventilationwithin 24 hours of birth compared with face mask (very low certainty).

1 finding from 1 review

Nasal interfaces (single nasal prong, binasal prongs (long or short), or nasal masks) vs face mask

Intubation and mechanical ventilation outside the DR during hospitalisation · term and preterm infants resuscitated at birth, using positive pressure ventilation

It is very uncertain whether nasal interfaces (single nasal prong, binasal prongs (long or… changes intubation and mechanical ventilation outside the DR during… compared with face mask (very low certainty).

1 finding from 1 review

Nasal interfaces (single nasal prong, binasal prongs (long or short), or nasal masks) vs face mask

Air leak (any) · term and preterm infants resuscitated at birth, using positive pressure ventilation

Nasal interfaces (single nasal prong, binasal prongs (long or… showed no clear difference in air leaks compared with face mask (low certainty).

1 finding from 1 review

Nasal interfaces (single nasal prong, binasal prongs (long or short), or nasal masks) vs face mask

Oxygen requirement at 36 weeks' postmenstrual age · term and preterm infants resuscitated at birth, using positive pressure ventilation

Nasal interfaces (single nasal prong, binasal prongs (long or… showed no clear difference in the need for supplemental oxygen at 36 weeks' corrected gestational… compared with face mask (low certainty).

1 finding from 1 review

Nasal interfaces (single nasal prong, binasal prongs (long or short), or nasal masks) vs face mask

Cranial ultrasound abnormalities (IVH grade ≥ 3 or cystic periventricular leukomalacia) · term and preterm infants resuscitated at birth, using positive pressure ventilation

It is very uncertain whether nasal interfaces (single nasal prong, binasal prongs (long or… changes cranial ultrasound abnormalities (IVH grade ≥ 3 or cystic… compared with face mask (very low certainty).

1 finding from 1 review

Botulinum toxin vs surgery

Proportion of participants who achieved binocular single vision at 6 or 12 months · adults and children with strabismus

Botulinum toxin showed no clear difference in proportion of participants who achieved binocular single vision at 6… compared with surgery (low certainty).

1 finding from 1 review

Intervention not reported

Treatment time: time for a single nebulised treatment (min) · children and adults with cystic fibrosis
1 finding from 1 review

Assistive technology for vision improvement interventions vs usual care or attention control

Health‐related quality of life ‐ all trials Higher scores indicate improved health‐related quality of life · Older people living in the community

Assistive technology for vision improvement interventions showed no clear difference in health‐related quality of life 1 trial of single‐lens glasses… compared with usual care or attention control (low certainty).

1 finding from 1 review

Intervention not reported

Total hip arthroplasty (single articulation) (3 RCTs; 306 participants)a · older adults (> 60 years of age) with intracapsular hip fractures; most fractures in the included studies were displaced

It is very uncertain whether the intervention changes total hip arthroplasty (single articulation) (3 RCTs; 306… (very low certainty).

1 finding from 1 review

Intervention not reported

Total hip arthroplasty (single articulation) (2 RCTs; 225 participants)a · older adults (> 60 years of age) with intracapsular hip fractures; most fractures in the included studies were displaced

It is very uncertain whether the intervention changes total hip arthroplasty (single articulation) (2 RCTs; 225… (very low certainty).

1 finding from 1 review

Albendazole vs placebo or no anthelmintics

Seizure recurrence ‐ participants with a single cyst · people with neurocysticercosis

Albendazole probably leads to lower seizure recurrence ‐ participants with a single cyst compared with placebo or no anthelmintics (moderate certainty).

1 finding from 1 review