Findings

What do systematic reviews say?

577 questions · 585 findings · 77 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 143 · 24.4%GRADE not reported 26 · 4.4%Very low 145 · 24.8%Low 156 · 26.7%Moderate 98 · 16.8%High 17 · 2.9%

Inhalation before vs after airway clearance techniques

FVC · adults and children with cystic fibrosis

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Summary of findings: fat‐soluble vitamin E vs control

FEV1 % predicted: absolute change from baseline · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin E supplementation in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: water‐soluble vitamin E vs control

FEV1 % predicted: absolute change from baseline · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin E supplementation in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

FEV1 change from start of treatment (% predicted) · adults and children with cystic fibrosis and P aeruginosa

1 finding from 1 review

Standard versus biofilm antimicrobial susceptibility testing to guide antibiotic therapy in cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 34 participants
Moderate

Vitamin D 100,000 IU/month vs 12,000 IU/month

Pain: presence of pain (slight or moderate) at 1 year · people with sickle cell disease

Vitamin D 100,000 IU/month showed no clear difference in presence of pain compared with 12,000 IU/month (moderate certainty).

1 finding from 1 review

Vitamin D supplementation for sickle cell disease 2020 · Cochrane Headline outcomes only
RR 1 [0.62, 1.62]
1 study · 62 participants
Moderate

HC (15 mg/m²/day) vs PD (3 mg/m²/day) versus DXA (0.3 mg/m²/day)

Prevention of adrenal crisis · people with CAH

The review found no eligible studies for this question.

1 finding from 1 review

Glucocorticoid replacement regimens for treating congenital adrenal hyperplasia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

HC (15 mg/m²/day) vs PD (3 mg/m²/day) versus DXA (0.3 mg/m²/day)

Presence of osteopenia · people with CAH

The review found no eligible studies for this question.

1 finding from 1 review

Glucocorticoid replacement regimens for treating congenital adrenal hyperplasia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

HC (15 mg/m²/day) vs PD (3 mg/m²/day) versus DXA (0.3 mg/m²/day)

Presence of testicular or ovarian adrenal rest tumours · people with CAH

The review found no eligible studies for this question.

1 finding from 1 review

Glucocorticoid replacement regimens for treating congenital adrenal hyperplasia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

HC (10 mg/m²/day to 15 mg/m²/day) vs PD (2.4 mg/m²/day to 3.5 mg/m²/day)

Prevention of adrenal crisis · people with CAH

The review found no eligible studies for this question.

1 finding from 1 review

Glucocorticoid replacement regimens for treating congenital adrenal hyperplasia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

HC (10 mg/m²/day to 15 mg/m²/day) vs PD (2.4 mg/m²/day to 3.5 mg/m²/day)

Presence of osteopenia · people with CAH

The review found no eligible studies for this question.

1 finding from 1 review

Glucocorticoid replacement regimens for treating congenital adrenal hyperplasia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

HC (10 mg/m²/day to 15 mg/m²/day) vs PD (2.4 mg/m²/day to 3.5 mg/m²/day)

Presence of testicular or ovarian adrenal rest tumours · people with CAH

The review found no eligible studies for this question.

1 finding from 1 review

Glucocorticoid replacement regimens for treating congenital adrenal hyperplasia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

HC (15 mg/m²/day) vs HC (25 mg/m²/day) with fludrocortisone (0.1 mg/day)

Prevention of adrenal crisis · people with CAH

The review found no eligible studies for this question.

1 finding from 1 review

Glucocorticoid replacement regimens for treating congenital adrenal hyperplasia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

HC (15 mg/m²/day) vs HC (25 mg/m²/day) with fludrocortisone (0.1 mg/day)

Presence of osteopenia · people with CAH

The review found no eligible studies for this question.

1 finding from 1 review

Glucocorticoid replacement regimens for treating congenital adrenal hyperplasia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

HC (15 mg/m²/day) vs HC (25 mg/m²/day) with fludrocortisone (0.1 mg/day)

Presence of testicular or ovarian adrenal rest tumours · people with CAH

The review found no eligible studies for this question.

1 finding from 1 review

Glucocorticoid replacement regimens for treating congenital adrenal hyperplasia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

HC (13.5 mg/m²/day to 15.5 mg/m²/day): high morning dose vs high evening dose

Prevention of adrenal crisis · people with CAH

The review found no eligible studies for this question.

1 finding from 1 review

Glucocorticoid replacement regimens for treating congenital adrenal hyperplasia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

HC (13.5 mg/m²/day to 15.5 mg/m²/day): high morning dose vs high evening dose

Presence of osteopenia · people with CAH

The review found no eligible studies for this question.

1 finding from 1 review

Glucocorticoid replacement regimens for treating congenital adrenal hyperplasia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

HC (13.5 mg/m²/day to 15.5 mg/m²/day): high morning dose vs high evening dose

Presence of testicular or ovarian adrenal rest tumours · people with CAH

The review found no eligible studies for this question.

1 finding from 1 review

Glucocorticoid replacement regimens for treating congenital adrenal hyperplasia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Probiotics vs placebo

FEV1 % predicted · children and adults with CF

1 finding from 1 review

Probiotics for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 284 participants
Low

NSAIDs vs placebo

Annual rate of change in % predicted FEV1 All participants · adults and children with cystic fibrosis

1 finding from 1 review

Oral non‐steroidal anti‐inflammatory drug therapy for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 226 participants
Moderate

NSAIDs vs placebo

Annual rate of change in % predicted FEV1 Subgroup: under 13 years of age · adults and children with cystic fibrosis

1 finding from 1 review

Oral non‐steroidal anti‐inflammatory drug therapy for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 147 participants
Moderate