Cochrane · systematic review · CD008816
Timing of hypertonic saline inhalation for cystic fibrosis
Elkins, M, Dentice, R · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Cystic Fibrosis and Genetic DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
11
No studies
10
Included studies
NR
No studies 10 · 47.6%Ungraded 0 · 0%Very low 0 · 0%Low 11 · 52.4%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Inhalation before compared with during airway clearance techniques for cystic fibrosis
Population: adults and children with cystic fibrosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
FEV1 % predicted Inhalation before vs during airway clearance techniques | no estimate extracted | 2 studies · 63 participants | Low Downgraded: risk of bias, indirectness |
FVC % predicted Inhalation before vs during airway clearance techniques | no estimate extracted | 1 study · 50 participants | Low Downgraded: risk of bias, indirectness |
QoL Inhalation before vs during airway clearance techniques | no estimate extracted | NR | No studies |
Symptom scores Inhalation before vs during airway clearance techniques | no estimate extracted | 3 studies · 76 participants | Low Downgraded: risk of bias, indirectness |
Measures of sputum clearance: sputum wet weight immediately (g) Inhalation before vs during airway clearance techniques | no estimate extracted | 2 studies · 26 participants | Low Downgraded: risk of bias, indirectness |
LCI Inhalation before vs during airway clearance techniques | no estimate extracted | 1 study · 13 participants | Low Downgraded: risk of bias, indirectness |
Adverse events Inhalation before vs during airway clearance techniques | no estimate extracted | NR | No studies |
Inhalation before compared with after airway clearance techniques for cystic fibrosis
Population: adults and children with cystic fibrosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
FEV1 % predicted Inhalation before vs after airway clearance techniques | no estimate extracted | 1 study · 50 participants | Low Downgraded: risk of bias, indirectness |
FVC % predicted Inhalation before vs after airway clearance techniques | no estimate extracted | 1 study · 50 participants | Low Downgraded: risk of bias, indirectness |
QoL Inhalation before vs after airway clearance techniques | no estimate extracted | NR | No studies |
Symptom scores Inhalation before vs after airway clearance techniques | no estimate extracted | 1 study · 50 participants | Low Downgraded: risk of bias, indirectness |
Measures of sputum clearance Inhalation before vs after airway clearance techniques | no estimate extracted | NR | No studies |
LCI Inhalation before vs after airway clearance techniques | no estimate extracted | NR | No studies |
Adverse events Inhalation before vs after airway clearance techniques | no estimate extracted | NR | No studies |
Inhalation during compared with after airway clearance techniques for cystic fibrosis
Population: adults and children with cystic fibrosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
FEV1 % predicted Inhalation during vs after airway clearance techniques | no estimate extracted | 1 study · 50 participants | Low Downgraded: risk of bias, indirectness |
FVC % predicted Inhalation during vs after airway clearance techniques | no estimate extracted | 1 study · 50 participants | Low Downgraded: risk of bias, indirectness |
QoL Inhalation during vs after airway clearance techniques | no estimate extracted | NR | No studies |
Symptom scores Inhalation during vs after airway clearance techniques | no estimate extracted | 1 study · 50 participants | Low Downgraded: risk of bias, indirectness |
Measures of sputum clearance Inhalation during vs after airway clearance techniques | no estimate extracted | NR | No studies |
LCI Inhalation during vs after airway clearance techniques | no estimate extracted | NR | No studies |
Adverse events Inhalation during vs after airway clearance techniques | no estimate extracted | NR | No studies |