Cochrane · systematic review · CD001505
Oral non‐steroidal anti‐inflammatory drug therapy for lung disease in cystic fibrosis
Lands, LC, Stanojevic, S · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Cystic Fibrosis and Genetic DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 7 · 100%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Summary of findings: non‐steroidal anti‐inflammatory drugs compared with placebo for lung disease in cystic fibrosis
Population: adults and children with cystic fibrosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Annual rate of change in % predicted FEV1 All participants Summary of findings: non‐steroidal anti‐inflammatory drugs vs placebo | no estimate extracted | 2 studies · 226 participants | Moderate Downgraded: risk of bias |
Annual rate of change in % predicted FEV1 Subgroup: under 13 years of age Summary of findings: non‐steroidal anti‐inflammatory drugs vs placebo | no estimate extracted | 2 studies · 147 participants | Moderate Downgraded: risk of bias |
Annual rate of change in % predicted FEV1 Subgroup: over 13 years of age Summary of findings: non‐steroidal anti‐inflammatory drugs vs placebo | no estimate extracted | 2 studies · 79 participants | Moderate Downgraded: risk of bias |
Annual rate of change in % predicted FVC All participants Summary of findings: non‐steroidal anti‐inflammatory drugs vs placebo | no estimate extracted | 2 studies · 226 participants | Moderate Downgraded: risk of bias |
Annual rate of change in % predicted FVC Subgroup: Under 13 years of age Summary of findings: non‐steroidal anti‐inflammatory drugs vs placebo | no estimate extracted | 2 studies · 147 participants | Moderate Downgraded: risk of bias |
Annual rate of change in % predicted FVC Subgroup: Over 13 years of age Summary of findings: non‐steroidal anti‐inflammatory drugs vs placebo | no estimate extracted | 2 studies · 79 participants | Moderate Downgraded: risk of bias |
Proportion with at least 1 hospital admission Summary of findings: non‐steroidal anti‐inflammatory drugs vs placebo | OR 0.61 [0.37, 1.01] | 4 studies · 286 participants | Moderate Downgraded: risk of bias |