What do systematic reviews say?

Laser enamel preparation alone (Er,Cr:YSGG or CO2 laser) vs Acid-etching (phosphoric acid)

Both laser and acid-etching preparation were well accepted by patients (VAS, P = 1.000; ungraded, single study).

• The clinical effects of laser preparation of tooth surfaces for fissure sealants placement: a systematic review and… 2019 All outcomes

  Clinical (in vivo pit-and-fissure sealant placement)
  Kumar 2016 (Er,Cr:YSGG laser vs acid-etching): patient acceptance scored on a visual analogue scale; both preparations well accepted, P = 1.000; no significant difference.
  1 study · 50 participants
  GRADE not reported

Antidepressants plus benzodiazepines vs antidepressants alone

Antidepressants plus benzodiazepines showed no clear difference in acceptability of treatment (dropout for any reason) compared with antidepressants alone (moderate certainty).

• Antidepressants plus benzodiazepines for adults with major depression 2019 · Cochrane Headline outcomes only
  RR 0.76 [0.54, 1.07]
  10 studies · 731 participants
  Moderate

Adverse event outcomes for physical activity interventions vs control

• Interventions for preventing obesity in children 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 546 participants
  Moderate

Vaginal misoprostol vs surgical evacuation of uterus

Vaginal misoprostol showed no clear difference in woman’s satisfaction/acceptability of method compared with surgical evacuation of uterus (low certainty).

• Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
  RR 0.67 [0.4, 1.11]
  1 study · 45 participants
  Low

Vaginal misoprostol vs placebo

Vaginal misoprostol showed no clear difference in woman’s satisfaction/acceptability of method compared with placebo (low certainty).

• Medical treatment for early fetal death (less than 24 weeks) 2019 · Cochrane Headline outcomes only
  RR 1.17 [0.83, 1.64]
  1 study · 32 participants
  Low

Lithium vs valproate

Lithium showed no clear difference in acceptability: total withdrawals compared with valproate (high certainty).

• Lithium for acute mania 2019 · Cochrane Headline outcomes only
  OR 1.2 [0.86, 1.69]
  5 studies · 629 participants
  High

Lithium vs lamotrigine

It is very uncertain whether lithium changes acceptability: total withdrawals compared with lamotrigine (very low certainty).

• Lithium for acute mania 2019 · Cochrane Headline outcomes only
  OR 0.8 [0.5, 1.29]
  3 studies · 303 participants
  Very low

Lithium vs carbamazepine

Lithium showed no clear difference in acceptability: total withdrawals compared with carbamazepine (low certainty).

• Lithium for acute mania 2019 · Cochrane Headline outcomes only
  OR 0.2 [0.02, 1.94]
  1 study · 34 participants
  Low

Lithium vs QUETIAPINE

It is very uncertain whether lithium changes acceptability: total withdrawals compared with quetiapine (very low certainty).

• Lithium for acute mania 2019 · Cochrane Headline outcomes only
  OR 1.38 [0.83, 2.28]
  2 studies · 359 participants
  Very low

Lithium vs OLANZAPINE

Lithium may leads to higher acceptability: total withdrawals compared with olanzapine (low certainty).

• Lithium for acute mania 2019 · Cochrane Headline outcomes only
  OR 2.6 [1.13, 5.99]
  3 studies · 210 participants
  Low

Lithium vs placebo

Lithium showed no clear difference in acceptability: total withdrawals compared with placebo (moderate certainty).

• Lithium for acute mania 2019 · Cochrane Headline outcomes only
  OR 0.76 [0.46, 1.25]
  7 studies · 1353 participants
  Moderate

Lithium vs chlorpromazine

Lithium showed no clear difference in acceptability: total withdrawals compared with chlorpromazine (low certainty).

• Lithium for acute mania 2019 · Cochrane Headline outcomes only
  OR 1.75 [0.92, 3.31]
  2 studies · 262 participants
  Low

Lithium vs haloperidol

It is very uncertain whether lithium changes acceptability: total withdrawals compared with haloperidol (very low certainty).

• Lithium for acute mania 2019 · Cochrane Headline outcomes only
  OR 0.29 [0.03, 3.12]
  1 study · 30 participants
  Very low

Lithium vs Zuclopenthixol (Cis Z/Trans E isomer)

It is very uncertain whether lithium changes acceptability: total withdrawals compared with zuclopenthixol (very low certainty).

• Lithium for acute mania 2019 · Cochrane Headline outcomes only
  OR 0.78 [0.17, 3.49]
  1 study · 28 participants
  Very low

Lithium vs RISPERIDONE

Lithium probably leads to higher acceptability: total withdrawals compared with risperidone (moderate certainty).

• Lithium for acute mania 2019 · Cochrane Headline outcomes only
  OR 1.85 [1.02, 3.34]
  3 studies · 255 participants
  Moderate

Lithium vs ARIPIPRAZOLE

Lithium showed no clear difference in acceptability: total withdrawals compared with aripiprazole (moderate certainty).

• Lithium for acute mania 2019 · Cochrane Headline outcomes only
  OR 0.94 [0.6, 1.46]
  1 study · 315 participants
  Moderate

Lithium vs topiramate

Lithium showed no clear difference in acceptability: total withdrawals compared with topiramate (high certainty).

• Lithium for acute mania 2019 · Cochrane Headline outcomes only
  OR 1.28 [0.66, 2.48]
  2 studies · 1352 participants
  High

Lithium vs clonazepam

The review found no eligible studies for this question.

• Lithium for acute mania 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Lithium vs ECT

The review found no eligible studies for this question.

• Lithium for acute mania 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Lithium vs all antimanic agents

Lithium showed no clear difference in acceptability: total withdrawals compared with all antimanic agents (high certainty).

• Lithium for acute mania 2019 · Cochrane Headline outcomes only
  OR 1.16 [0.89, 1.52]
  24 studies · 4201 participants
  High